A new nano-biophotonics toolbox

Jesper Glückstad, Andrew Rafael Bañas, Darwin Palima

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    Abstract

    The science fiction inspired shrinking of macro-scale robotic manipulation and handling down to the micro- and nano-scale regime open new doors for exploiting the forces and torques of light for micro- and nanobiologic probing, actuation and control. A generic approach for optimizing light-matter interaction on these scales involves the combination of optimal light-sculpting with the use of optimized shapes in micro-robotics structures. Micro-fabrication processes such as two-photon photo-polymerization offer three-dimensional resolutions for creating custom-designed monolithic microstructures that can be equipped with optical trapping handles for convenient mechanical control using only optical forces. These microstructures can be effectively handled with simultaneous top- and side-view on our BioPhotonics Workstation to undertake six-degree-of-freedom optical actuation of two-photon polymerised microstructures equipped with features easily entering the submicron-regime. Aided by European collaborators who fabricated test structures with built-in waveguides for us, we were able to put the idea of optically steerable freestanding waveguides – coined: wave-guided optical waveguides - to the test using our BioPhotonics Workstation. We also propose using these techniques for generating two-photon real-time spatially sculpted light for the strongly emerging areas of neurophotonics and optogenetics.
    Original languageEnglish
    Publication date2013
    Publication statusPublished - 2013
    Event11th Mediterranean workshop and topical meeting: Novel optical materials and applications - Grand Hotel San Michele, Cetraro, Italy
    Duration: 10 Jun 201315 Jun 2013
    Conference number: 11

    Conference

    Conference11th Mediterranean workshop and topical meeting: Novel optical materials and applications
    Number11
    LocationGrand Hotel San Michele
    Country/TerritoryItaly
    CityCetraro
    Period10/06/201315/06/2013

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