A new efficient synthesis of isothiocyanates from amines using di-tert-butyl dicarbonate

Henrik Munch, Jon S. Hansen, Michael Pittelkow, Jørn B. Christensen, Ulrik Boas

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Alkyl and aryl amines are converted smoothly to the corresponding isothiocyanates via the dithiocarbamates in good to excellent yields using di-tert-butyl dicarbonate (Boc(2)O) and 1-3 mol% of DMAP or DABCO as catalyst. As most of the byproducts are volatile, the work-up involves simple evaporation of the reaction mixture.
    Original languageEnglish
    JournalTetrahedron Letters
    Volume49
    Issue number19
    Pages (from-to)3117-3119
    ISSN0040-4039
    DOIs
    Publication statusPublished - 2008

    Keywords

    • di-tert-butyl dicarbonate
    • amine
    • isothiocyanate
    • thiourea

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