A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators

Chengming Li; Peter Jeppe Madsen; Steven P. Armes; Andrew L. Lewis

doi:10.1002/anie.200600324

A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators

Chengming Li, Peter Jeppe Madsen, Steven P. Armes, Andrew L. Lewis

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

To rub gel into the wound: A thermoresponsive ABA triblock copolymer gelator with A=N-isopropylacrylamide and B=2- (methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide-based initiator. This triblock copolymer forms free-standing peptide-degradable micellar gels under physiologically relevant conditions.

Original language	English
Journal	Angewandte chemie-international edition
Volume	45
Issue number	21
Pages (from-to)	3510-3513
Number of pages	4
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.200600324
Publication status	Published - 2006
Externally published	Yes

Bibliographical note

Keywords

Biomimetic synthesis
Copolymers
Gels
Micelles
Peptide-induced degradation

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10.1002/anie.200600324

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title = "A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators",

abstract = "To rub gel into the wound: A thermoresponsive ABA triblock copolymer gelator with A=N-isopropylacrylamide and B=2- (methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide-based initiator. This triblock copolymer forms free-standing peptide-degradable micellar gels under physiologically relevant conditions. ",

keywords = "Biomimetic synthesis, Copolymers, Gels, Micelles, Peptide-induced degradation",

author = "Chengming Li and {Jeppe Madsen}, Peter and Armes, {Steven P.} and Lewis, {Andrew L.}",

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volume = "45",

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AU - Li, Chengming

AU - Jeppe Madsen, Peter

AU - Armes, Steven P.

AU - Lewis, Andrew L.

PY - 2006

Y1 - 2006

N2 - To rub gel into the wound: A thermoresponsive ABA triblock copolymer gelator with A=N-isopropylacrylamide and B=2- (methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide-based initiator. This triblock copolymer forms free-standing peptide-degradable micellar gels under physiologically relevant conditions.

AB - To rub gel into the wound: A thermoresponsive ABA triblock copolymer gelator with A=N-isopropylacrylamide and B=2- (methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide-based initiator. This triblock copolymer forms free-standing peptide-degradable micellar gels under physiologically relevant conditions.

KW - Biomimetic synthesis

KW - Copolymers

KW - Gels

KW - Micelles

KW - Peptide-induced degradation

U2 - 10.1002/anie.200600324

DO - 10.1002/anie.200600324

M3 - Journal article

SN - 1433-7851

VL - 45

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JO - Angewandte chemie-international edition

JF - Angewandte chemie-international edition

IS - 21

ER -

A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators

Abstract

Bibliographical note

Keywords

Access to Document

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