A multifunctional nanocomplex for enhanced cell uptake, endosomal escape and improved cancer therapeutic effect

Patrick V. Almeida, Mohammad-Ali Shahbazi, Alexandra Correia, Ermei Makila, Marianna Kemell, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Aim: To evaluate the chemotherapeutic potential of a novel multifunctional nanocomposite encapsulating both porous silicon (PSi) and gold (Au) nanoparticles in a polymeric nanocomplex. Materials & methods: The nanocomposite was physicochemically characterized and evaluated in vitro for biocompatibility, cellular internalization, endosomolytic properties, cytoplasmatic drug delivery and chemotherapeutic efficacy. Results: The nanocomposites were successfully produced and exhibited adequate physicochemical properties and superior in vitro cyto- and hemocompatibilities. The encapsulation of PSi nanoparticles in the nanocomplexes significantly enhanced their cellular internalization and enabled their endosomal escape, resulting in the efficient cytoplasmic delivery of these nanosystems. Sorafenibloaded nanocomposites showed a potent in vitro antiproliferative effect on MDA-MB-231 breast cancer cells. Conclusion: The multifunctional nanocomposite herein presented exhibits great potential as a chemotherapeutic nanoplatform.
    Original languageEnglish
    JournalNanomedicine
    Volume12
    Issue number12
    Pages (from-to)1401-1420
    Number of pages20
    ISSN1743-5889
    DOIs
    Publication statusPublished - 2017

    Cite this

    Almeida, P. V., Shahbazi, M-A., Correia, A., Makila, E., Kemell, M., Salonen, J., Hirvonen, J., & Santos, H. A. (2017). A multifunctional nanocomplex for enhanced cell uptake, endosomal escape and improved cancer therapeutic effect. Nanomedicine, 12(12), 1401-1420. https://doi.org/10.2217/nnm-2017-0034