A mouse model of the auditory nerve to study cochlear synaptopathy

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Abstract

Several non-human animal studies have demonstrated a permanent loss of auditory nerve (AN) fiber synapses after noise over-exposure, termed cochlear synaptopathy, without causing hair cell loss nor altering normal auditory thresholds (e.g., Kujawa and Liberman, 2009). Studies in human listeners are generally inconclusive, mainly because assessing the status of the AN in humans represents a major challenge. In a previous study, we proposed the use of envelope following responses (EFR) as a tool to investigate synaptopathy both in mice and humans (Encina-Llamas et al., under review; Parthasarathy et al., 2017). Similar patterns in synaptopathic mice and humans were found. The use of a "humanized" version of the AN model by Zilany et al. (2009, 2014) could qualitatively account for the patterns obtained in the human listeners. Nevertheless, the use of the original animal version of the AN model (based on the cat) failed to simulate EFRs in mice. It was argued that a species-specific AN model could improve the non-human animal simulations. Given that the mouse is the most used and best characterized species in connection with cochlear synaptopathy, the present study proposes a modification of the original AN model by Zilany et al. (2009, 2014) based on cat data adapted to the mouse
Original languageEnglish
Publication date2018
Number of pages1
Publication statusPublished - 2018
Event41st MidWinter Meeting of the Association for Research in Otolaryngology - Manchester Grand Hyatt, San Diego, United States
Duration: 9 Feb 201814 Feb 2018

Conference

Conference41st MidWinter Meeting of the Association for Research in Otolaryngology
LocationManchester Grand Hyatt
CountryUnited States
CitySan Diego
Period09/02/201814/02/2018

Cite this

Encina-Llamas, G., Dau, T., Harte, J. M., & Epp, B. (2018). A mouse model of the auditory nerve to study cochlear synaptopathy. Poster session presented at 41st MidWinter Meeting of the Association for Research in Otolaryngology, San Diego, United States.
Encina-Llamas, Gerard ; Dau, Torsten ; Harte, James Michael ; Epp, Bastian. / A mouse model of the auditory nerve to study cochlear synaptopathy. Poster session presented at 41st MidWinter Meeting of the Association for Research in Otolaryngology, San Diego, United States.1 p.
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note = "41st MidWinter Meeting of the Association for Research in Otolaryngology, ARO 2018 ; Conference date: 09-02-2018 Through 14-02-2018",

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Encina-Llamas, G, Dau, T, Harte, JM & Epp, B 2018, 'A mouse model of the auditory nerve to study cochlear synaptopathy', 41st MidWinter Meeting of the Association for Research in Otolaryngology, San Diego, United States, 09/02/2018 - 14/02/2018.

A mouse model of the auditory nerve to study cochlear synaptopathy. / Encina-Llamas, Gerard; Dau, Torsten; Harte, James Michael; Epp, Bastian.

2018. Poster session presented at 41st MidWinter Meeting of the Association for Research in Otolaryngology, San Diego, United States.

Research output: Contribution to conferencePosterResearchpeer-review

TY - CONF

T1 - A mouse model of the auditory nerve to study cochlear synaptopathy

AU - Encina-Llamas, Gerard

AU - Dau, Torsten

AU - Harte, James Michael

AU - Epp, Bastian

PY - 2018

Y1 - 2018

N2 - Several non-human animal studies have demonstrated a permanent loss of auditory nerve (AN) fiber synapses after noise over-exposure, termed cochlear synaptopathy, without causing hair cell loss nor altering normal auditory thresholds (e.g., Kujawa and Liberman, 2009). Studies in human listeners are generally inconclusive, mainly because assessing the status of the AN in humans represents a major challenge. In a previous study, we proposed the use of envelope following responses (EFR) as a tool to investigate synaptopathy both in mice and humans (Encina-Llamas et al., under review; Parthasarathy et al., 2017). Similar patterns in synaptopathic mice and humans were found. The use of a "humanized" version of the AN model by Zilany et al. (2009, 2014) could qualitatively account for the patterns obtained in the human listeners. Nevertheless, the use of the original animal version of the AN model (based on the cat) failed to simulate EFRs in mice. It was argued that a species-specific AN model could improve the non-human animal simulations. Given that the mouse is the most used and best characterized species in connection with cochlear synaptopathy, the present study proposes a modification of the original AN model by Zilany et al. (2009, 2014) based on cat data adapted to the mouse

AB - Several non-human animal studies have demonstrated a permanent loss of auditory nerve (AN) fiber synapses after noise over-exposure, termed cochlear synaptopathy, without causing hair cell loss nor altering normal auditory thresholds (e.g., Kujawa and Liberman, 2009). Studies in human listeners are generally inconclusive, mainly because assessing the status of the AN in humans represents a major challenge. In a previous study, we proposed the use of envelope following responses (EFR) as a tool to investigate synaptopathy both in mice and humans (Encina-Llamas et al., under review; Parthasarathy et al., 2017). Similar patterns in synaptopathic mice and humans were found. The use of a "humanized" version of the AN model by Zilany et al. (2009, 2014) could qualitatively account for the patterns obtained in the human listeners. Nevertheless, the use of the original animal version of the AN model (based on the cat) failed to simulate EFRs in mice. It was argued that a species-specific AN model could improve the non-human animal simulations. Given that the mouse is the most used and best characterized species in connection with cochlear synaptopathy, the present study proposes a modification of the original AN model by Zilany et al. (2009, 2014) based on cat data adapted to the mouse

M3 - Poster

ER -

Encina-Llamas G, Dau T, Harte JM, Epp B. A mouse model of the auditory nerve to study cochlear synaptopathy. 2018. Poster session presented at 41st MidWinter Meeting of the Association for Research in Otolaryngology, San Diego, United States.