A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

Marc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant, Luke R. Odell

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups. This journal is
Original languageEnglish
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number7
Pages (from-to)2044-2054
Number of pages11
ISSN1477-0520
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Functional groups
  • Iminium
  • Microwave assisted
  • Multicomponent synthesis
  • Multicomponents
  • Reaction sequences
  • Synthesis (chemical)

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