A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

Marc Y. Stevens; Krzysztof Wieckowski; Peng Wu; Rajiv T. Sawant; Luke R. Odell

doi:10.1039/c4ob02417f

A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

Marc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant, Luke R. Odell

Uppsala University

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups. This journal is

Original language	English
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	7
Pages (from-to)	2044-2054
Number of pages	11
ISSN	1477-0520
DOIs	https://doi.org/10.1039/c4ob02417f
Publication status	Published - 2015
Externally published	Yes

Keywords

Functional groups
Iminium
Microwave assisted
Multicomponent synthesis
Multicomponents
Reaction sequences
Synthesis (chemical)

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10.1039/c4ob02417f

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abstract = "A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups. This journal is",

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AU - Sawant, Rajiv T.

AU - Odell, Luke R.

PY - 2015

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AB - A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups. This journal is

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KW - Microwave assisted

KW - Multicomponent synthesis

KW - Multicomponents

KW - Reaction sequences

KW - Synthesis (chemical)

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A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

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Keywords

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