A microfluidic toolbox for the development of in-situ product removal strategies in biocatalysis

Søren Heintz, Aleksandar Mitic, Rolf Hoffmeyer Ringborg, Ulrich Krühne, John Woodley, Krist Gernaey

Research output: Contribution to journalReviewResearchpeer-review

365 Downloads (Pure)

Abstract

A microfluidic toolbox for accelerated development of biocatalytic processes has great potential. This is especially the case for the development of advanced biocatalytic process concepts, where reactors and product separation methods are closely linked together to intensify the process performance, e.g., by the use of in-situ product removal (ISPR).This review provides a general overview of currently available tools in a microfluidic toolbox and how this toolbox can be applied to the development of advanced biocatalytic process concepts. Emphasis is placed on describing the possibilities and advantages of the microfluidic toolbox that are difficult to achieve with conventional batch-process-based technologies. Application of this microfluidic toolbox will potentially make it possible to intensify biocatalytic reactions and thereby facilitate the development towards novel and advanced biocatalytic processes, which in many cases have proven too difficult in conventional batch equipment.
Original languageEnglish
JournalJournal of Flow Chemistry
Volume6
Issue number1
Pages (from-to)18–26
ISSN2062-249X
DOIs
Publication statusPublished - 2016

Keywords

  • Microfluidics
  • In-situ product removal (ISPR)
  • Process intensification
  • Biocatalysis
  • Process development

Fingerprint Dive into the research topics of 'A microfluidic toolbox for the development of in-situ product removal strategies in biocatalysis'. Together they form a unique fingerprint.

Cite this