A Method To Create Reference Maps for Evaluation of Ultrasound Images of Carotid Atherosclerotic Plaque

Jens E. Wilhjelm, M. S. Jensen, Kim Gammelmark, B. Sahl, Kjeld Martinsen, J. U. Hansen, T. Brandt, S. K. Jespersen, E. Falk, K. E. Fredfeldt, H. Sillesen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Ten formalin-fixed atherosclerotic carotid plaques removed by endarterectomy were molded into rectangular agar blocks containing fiducial markers on the top surface. Plaque and fiducial markers were imaged with 3-D multiangle ultrasound (US) spatial compounding as well as planar X ray. Subsequently, the blocks were decalcified, sliced, photographed and analyzed histologically. This gave a total of 123 slices. The plaque regions of the photographs were outlined and the outline adjusted to partly compensate for occasional displacement during slicing. Inside this outline, the material constitutions were found by incorporating the histologic information. From this set, slices with 1. too much tissue displacement due to cutting or 2. lack of identification of calcification as found by x ray, were removed. This resulted in 53 reference maps. The material types identified covered soft tissues, fibrous tissue, calcified tissue and unidentified tissues. The 53 reference maps can be used for direct automated quantitative comparison with US images.
    Original languageEnglish
    JournalUltrasound in Medicin and Biology
    Volume30
    Issue number9
    Pages (from-to)1119-1131
    ISSN0301-5629
    Publication statusPublished - 2004

    Fingerprint

    Dive into the research topics of 'A Method To Create Reference Maps for Evaluation of Ultrasound Images of Carotid Atherosclerotic Plaque'. Together they form a unique fingerprint.

    Cite this