A method of stabilizing mrna

Steen Pedersen; Kim Sneppen; Margit Pedersen; Sine Svenningsen; Mitarai Namiko

A method of stabilizing mrna

Steen Pedersen (Inventor)
, Kim Sneppen (Inventor)
, Margit Pedersen (Inventor)
, Sine Svenningsen (Inventor)
, Mitarai Namiko (Inventor)

University of Copenhagen

Research output: Patent

Abstract

There is provided a method to increase the production of a desired protein in a microorganism by introduction of slowly translated codons in the encoding DNA gene sequence capable of slowing down the translation speed of the ribosomes moving along the mRNA, whereby the ribosomes protect the mRNA from being enzymatically degraded. This increases the stability of the mRNA transcript and thus results in an increased production of the desired protein. Moreover, there is provided a method of decreasing the half-life of a mRNA transcript from a gene encoding a peptide.

Original language	English
Patent number	2011141027
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Publication status	Published - 2011
Externally published	Yes

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title = "A method of stabilizing mrna",

abstract = "There is provided a method to increase the production of a desired protein in a microorganism by introduction of slowly translated codons in the encoding DNA gene sequence capable of slowing down the translation speed of the ribosomes moving along the mRNA, whereby the ribosomes protect the mRNA from being enzymatically degraded. This increases the stability of the mRNA transcript and thus results in an increased production of the desired protein. Moreover, there is provided a method of decreasing the half-life of a mRNA transcript from a gene encoding a peptide.",

author = "Steen Pedersen and Kim Sneppen and Margit Pedersen and Sine Svenningsen and Mitarai Namiko",

year = "2011",

language = "English",

type = "Patent",

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TY - PAT

T1 - A method of stabilizing mrna

AU - Pedersen, Steen

AU - Sneppen, Kim

AU - Pedersen, Margit

AU - Svenningsen, Sine

AU - Namiko, Mitarai

PY - 2011

Y1 - 2011

N2 - There is provided a method to increase the production of a desired protein in a microorganism by introduction of slowly translated codons in the encoding DNA gene sequence capable of slowing down the translation speed of the ribosomes moving along the mRNA, whereby the ribosomes protect the mRNA from being enzymatically degraded. This increases the stability of the mRNA transcript and thus results in an increased production of the desired protein. Moreover, there is provided a method of decreasing the half-life of a mRNA transcript from a gene encoding a peptide.

AB - There is provided a method to increase the production of a desired protein in a microorganism by introduction of slowly translated codons in the encoding DNA gene sequence capable of slowing down the translation speed of the ribosomes moving along the mRNA, whereby the ribosomes protect the mRNA from being enzymatically degraded. This increases the stability of the mRNA transcript and thus results in an increased production of the desired protein. Moreover, there is provided a method of decreasing the half-life of a mRNA transcript from a gene encoding a peptide.

M3 - Patent

M1 - 2011141027

ER -

A method of stabilizing mrna

Abstract

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