Abstract
Disclosed is a method for preparing microparticles for drug delivery. The method comprises providing a mold comprising multiple individual, open compartments arranged on a first surface of the mold. The open compartments are separated from each other by one or more edges. Each edge has a width of 5 µm or less. The method comprises coating the first surface of the mold with a mold layer comprising a biocompatible and/or biodegradable material having a first release characteristic at a first condition. The method comprises loading the compartments coated with the mold layer with a pharmaceutical composition comprising a drug substance. The method comprises coating the first surface of the mold with a top layer comprising a biocompatible and/or biodegradable material having a second release characteristic at the first condition for provision of closed microparticles in the multiple individual compartments. The method comprises separating the closed microparticles by cutting the mold layer and the top layer using the one or more edges. By cutting the mold layer and the top layer using the one or more edges discrete microparticles are provided.
| Original language | English |
|---|---|
| IPC | A61K 38/ 00 A I |
| Patent number | WO2024184188 |
| Filing date | 03/03/2023 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 03/03/2023 |
| Priority number | EP20230159956 |
| Publication status | Published - 12 Sept 2024 |