A method for improved glycerol utilization in yeast

Tomas Strucko (Inventor), Jochen Förster (Inventor), Katharina Zirngibl (Inventor), Kiran Raosaheb Patil (Inventor)

Research output: Patent

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Abstract

The invention provides GM yeast strains for use as cell factories that are capable of using the waste product, glycerol, as sole carbon source, without the addition of an amino acid supplement. The invention additionally teaches how to modify existing yeast strains to have these advantageous properties, whereby the level of glycerol kinase activity (EC:2.7.1.30) is increased and the expression of genes encoding functional alpha-ketoglutarase complex activity (EC:2.7.1.30) and E2 ubiquitin-conjugating enzyme activity (EC:2.3.2.23) are inactivated.
Original languageEnglish
IPCC12N1/16; C12N1/18; C12N1/19; C12N9/02; C12N9/10; C12N9/12; C12P1/02; C12P7/06
Patent numberWO2018127572
Filing date12/07/2018
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date05/01/2017
Priority numberEP20170150378
Publication statusPublished - 2018

Cite this

Strucko, T., Förster, J., Zirngibl, K., & Patil, K. R. (2018). IPC No. C12N1/16; C12N1/18; C12N1/19; C12N9/02; C12N9/10; C12N9/12; C12P1/02; C12P7/06. A method for improved glycerol utilization in yeast. (Patent No. WO2018127572 ).