A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

Peng Wu, Anders Emil O'Hanlon Cohrt, Rico Petersen, Rémy Morgentin, Hugues Lemoine, Carine Roche, Anthony Willaume, Mads Hartvig Clausen, Thomas Eiland Nielsen

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Abstract

A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.
Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume14
Issue number29
Pages (from-to)6947-6950
Number of pages4
ISSN1477-0520
DOIs
Publication statusPublished - 2016

Bibliographical note

This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.

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