A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

Peng Wu; Anders Emil O'Hanlon Cohrt; Rico Petersen; Rémy Morgentin; Hugues Lemoine; Carine Roche; Anthony Willaume; Mads Hartvig Clausen; Thomas Eiland Nielsen

doi:10.1039/c6ob01148a

A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

Peng Wu, Anders Emil O'Hanlon Cohrt, Rico Petersen, Rémy Morgentin, Hugues Lemoine, Carine Roche, Anthony Willaume, Mads Hartvig Clausen, Thomas Eiland Nielsen

Department of Chemistry

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Abstract

A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.

Original language	English
Journal	Organic & Biomolecular Chemistry
Volume	14
Issue number	29
Pages (from-to)	6947-6950
Number of pages	4
ISSN	1477-0520
DOIs	https://doi.org/10.1039/c6ob01148a
Publication status	Published - 2016

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This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.

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Wu, Peng ; Cohrt, Anders Emil O'Hanlon ; Petersen, Rico ; Morgentin, Rémy ; Lemoine, Hugues ; Roche, Carine ; Willaume, Anthony ; Clausen, Mads Hartvig ; Nielsen, Thomas Eiland. / A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production. In: Organic & Biomolecular Chemistry. 2016 ; Vol. 14, No. 29. pp. 6947-6950.

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A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production. / Wu, Peng; Cohrt, Anders Emil O'Hanlon; Petersen, Rico; Morgentin, Rémy; Lemoine, Hugues; Roche, Carine; Willaume, Anthony; Clausen, Mads Hartvig; Nielsen, Thomas Eiland.

In: Organic & Biomolecular Chemistry, Vol. 14, No. 29, 2016, p. 6947-6950.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Morgentin, Rémy

AU - Lemoine, Hugues

AU - Roche, Carine

AU - Willaume, Anthony

AU - Clausen, Mads Hartvig

AU - Nielsen, Thomas Eiland

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AB - A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.

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DO - 10.1039/c6ob01148a

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JO - Organic & Biomolecular Chemistry

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A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

Abstract

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