Abstract
A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.
Original language | English |
---|---|
Journal | Organic & Biomolecular Chemistry |
Volume | 14 |
Issue number | 29 |
Pages (from-to) | 6947-6950 |
Number of pages | 4 |
ISSN | 1477-0520 |
DOIs | |
Publication status | Published - 2016 |