Our muscles are metabolically flexible, i.e., they are capable of `switching' between two types of oxidation: (1) when fasting, a predominantly lipid oxidation with high rates of fatty acid uptake, and (2) when fed, suppression of lipid oxidation in favour of increased glucose uptake, oxidation and storage, in response to insulin. One of the many manifestations of obesity and Type 2 diabetes is an insulin resistance of the skeletal muscles, which suppresses this metabolic switch. This talk describes recent development of a low-dimensional system of ODEs that model the metabolic switch, displaying a sensitivity to insulin concentration which matches well with clinical data.
|Publication status||Published - 2008|
|Event||Joint Mathematicsl Weekend - University of Copenhagen|
Duration: 1 Jan 2008 → …
|Conference||Joint Mathematicsl Weekend|
|City||University of Copenhagen|
|Period||01/01/2008 → …|