A mathematical model of how non-adherence to HIV management guidelines for infected newborns contribute to the spread of HIV/AIDS

Ofosuhene O. Apenteng, Mavis Pearl Kwabla, Noor Azina Ismail, Kafilah Lola Gold

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Each year, millions of children are born with human immunodeficiency virus (HIV), a quarter of whom adhere poorly to HIV treatment guidelines. This study uses a simple mathematical model to investigate the basic dynamic processes by which infected newborns under treatment progress to AIDS and contribute to its spread. The results indicate that the disease-free steady state is unstable, raising substantial concern from the public health point of view. The results show that the fraction of newborns who fail to adhere to the HIV management guidelines (30%) significantly contributes to the spread of HIV. However, the rate of HIV-positive newborns under treatment therapy is significant. This study agrees that only a small proportion of HIV-positive newborns adhere to management guidelines. These analyses should yield significant knowledge to advance our understanding of HIV infection in the early stages of life.
Original languageEnglish
JournalJournal of Hiv/aids and Social Services
Number of pages13
ISSN1538-151x
DOIs
Publication statusPublished - 2021

Keywords

  • HIV diseases
  • Reproduction number
  • Sensitivity analysis
  • Transmission mathematical modeling
  • Treatment therapy

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