A Mathematical Model for Simultaneous Saccharification and Co-fermentation (SSCF) of C6 and C5 Sugars

Ricardo Morales Rodriguez, Krist Gernaey, Anne S. Meyer, Gürkan Sin

Research output: Contribution to journalJournal articleResearchpeer-review


Reliable production of biofuels and specifically bioethanol has attracted a significant amount of research recently. Within this context, this study deals with dynamic simulation of bioethanol production processes and in particular aims at developing a mathematical model for describing simultaneous saccharification and co-fermentation (SSCF) of C6 and C5 sugars. The model is constructed by combining existing mathematical models for enzymatic hydrolysis and co-fermentation. An inhibition of ethanol on cellulose conversion is introduced in order to increase the reliability. The mathematical model for the SSCF is verified by comparing the model predictions with experimental data obtained from the ethanol production based on kraft paper mill sludge. When fitting the model to the data, only the yield coefficients for glucose and xylose metabolism were fine-tuned, which were found to be 0.43 g·g−1 (ethanol/glucose) and 0.35 g·g−1 (ethanol/xylose) respectively. These promising validation results encourage further model application to evaluate different process configurations for lignocellulosic bioethanol technology.
Original languageEnglish
JournalChinese Journal of Chemical Engineering
Issue number2
Pages (from-to)185-191
Publication statusPublished - 2011

Bibliographical note

Supported by the Mexican National Council for Science and Technology (CONACyT# 118903) and the Danish Research Council for Technology and Production Sciences (FTP# 274-07-0339).


  • Simultaneous saccharification and co-fermentation
  • Dynamic modeling
  • Bioethanol

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