TY - JOUR
T1 - A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
AU - Hansen, Lea B. S.
AU - Roager, Henrik M.
AU - Søndertoft, Nadja B.
AU - Gøbel, Rikke J.
AU - Kristensen, Mette
AU - Vallès-Colomer, Mireia
AU - Vieira-Silva, Sara
AU - Ibrügger, Sabine
AU - Lind, Mads V.
AU - Mærkedahl, Rasmus B.
AU - Bahl, Martin Iain
AU - Madsen, Mia L
AU - Havelund, Jesper
AU - Falony, Gwen
AU - Tetens, Inge
AU - Nielsen, Trine
AU - Allin, Kristine H.
AU - Frandsen, Henrik L
AU - Hartmann, Bolette
AU - Holst, Jens Juul
AU - Sparholt, Morten H.
AU - Holck, Jesper
AU - Blennow, Andreas
AU - Moll, Janne Marie
AU - Meyer, Anne S.
AU - Hoppe, Camilla
AU - Poulsen, Jørgen H.
AU - Carvalho, Vera
AU - Sagnelli, Domenico
AU - Dalgaard, Marlene Danner
AU - Christensen, Anders F.
AU - Lydolph, Magnus Christian
AU - Ross, Alastair B
AU - Villas-Bôas, Silas
AU - Brix, Susanne
AU - Sicheritz-Pontén, Thomas
AU - Buschard, Karsten
AU - Linneberg, Allan
AU - Rumessen, Jüri J.
AU - Ekstrøm, Claus T.
AU - Ritz, Christian
AU - Kristiansen, Karsten
AU - Nielsen, H. Bjørn
AU - Vestergaard, Henrik
AU - Færgeman, Nils J.
AU - Raes, Jeroen
AU - Frøkiær, Hanne
AU - Hansen, Torben
AU - Gupta, Ramneek
AU - Licht, Tine Rask
AU - Pedersen, Oluf
PY - 2018
Y1 - 2018
N2 - Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
AB - Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
U2 - 10.1038/s41467-018-07019-x
DO - 10.1038/s41467-018-07019-x
M3 - Journal article
C2 - 30425247
VL - 9
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 4630
ER -