A key region in the human parietal cortex for processing proprioceptive hand feedback during reaching movements

Alexandra Reichenbach, Axel Thielscher, Angelika Peer, Heinrich H. Bülthoff, Jean-Pierre Bresciani

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Seemingly effortless, we adjust our movements to continuously changing environments. After initiation of a goal-directed movement, the motor command is under constant control of sensory feedback loops. The main sensory signals contributing to movement control are vision and proprioception. Recent neuroimaging studies have focused mainly on identifying the parts of the posterior parietal cortex (PPC) that contribute to visually guided movements. We used event-related TMS and force perturbations of the reaching hand to test whether the same sub-regions of the left PPC contribute to the processing of proprioceptive-only and of multi-sensory information about hand position when reaching for a visual target. TMS over two distinct stimulation sites elicited differential effects: TMS applied over the posterior part of the medial intraparietal sulcus (mIPS) compromised reaching accuracy when proprioception was the only sensory information available for correcting the reaching error. When visual feedback of the hand was available, TMS over the anterior intraparietal sulcus (aIPS) prolonged reaching time. Our results show for the first time the causal involvement of the posterior mIPS in processing proprioceptive feedback for online reaching control, and demonstrate that distinct cortical areas process proprioceptive-only and multi-sensory information for fast feedback corrections.
Original languageEnglish
JournalNeuroImage
Volume84
Pages (from-to)615-625
ISSN1053-8119
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Motor control
  • On-line control
  • Posterior parietal cortex
  • Proprioception
  • Reaching
  • Transcranial magnetic stimulation

Cite this

Reichenbach, Alexandra ; Thielscher, Axel ; Peer, Angelika ; Bülthoff, Heinrich H. ; Bresciani, Jean-Pierre. / A key region in the human parietal cortex for processing proprioceptive hand feedback during reaching movements. In: NeuroImage. 2014 ; Vol. 84. pp. 615-625.
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abstract = "Seemingly effortless, we adjust our movements to continuously changing environments. After initiation of a goal-directed movement, the motor command is under constant control of sensory feedback loops. The main sensory signals contributing to movement control are vision and proprioception. Recent neuroimaging studies have focused mainly on identifying the parts of the posterior parietal cortex (PPC) that contribute to visually guided movements. We used event-related TMS and force perturbations of the reaching hand to test whether the same sub-regions of the left PPC contribute to the processing of proprioceptive-only and of multi-sensory information about hand position when reaching for a visual target. TMS over two distinct stimulation sites elicited differential effects: TMS applied over the posterior part of the medial intraparietal sulcus (mIPS) compromised reaching accuracy when proprioception was the only sensory information available for correcting the reaching error. When visual feedback of the hand was available, TMS over the anterior intraparietal sulcus (aIPS) prolonged reaching time. Our results show for the first time the causal involvement of the posterior mIPS in processing proprioceptive feedback for online reaching control, and demonstrate that distinct cortical areas process proprioceptive-only and multi-sensory information for fast feedback corrections.",
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A key region in the human parietal cortex for processing proprioceptive hand feedback during reaching movements. / Reichenbach, Alexandra; Thielscher, Axel; Peer, Angelika; Bülthoff, Heinrich H.; Bresciani, Jean-Pierre.

In: NeuroImage, Vol. 84, 2014, p. 615-625.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - A key region in the human parietal cortex for processing proprioceptive hand feedback during reaching movements

AU - Reichenbach, Alexandra

AU - Thielscher, Axel

AU - Peer, Angelika

AU - Bülthoff, Heinrich H.

AU - Bresciani, Jean-Pierre

PY - 2014

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AB - Seemingly effortless, we adjust our movements to continuously changing environments. After initiation of a goal-directed movement, the motor command is under constant control of sensory feedback loops. The main sensory signals contributing to movement control are vision and proprioception. Recent neuroimaging studies have focused mainly on identifying the parts of the posterior parietal cortex (PPC) that contribute to visually guided movements. We used event-related TMS and force perturbations of the reaching hand to test whether the same sub-regions of the left PPC contribute to the processing of proprioceptive-only and of multi-sensory information about hand position when reaching for a visual target. TMS over two distinct stimulation sites elicited differential effects: TMS applied over the posterior part of the medial intraparietal sulcus (mIPS) compromised reaching accuracy when proprioception was the only sensory information available for correcting the reaching error. When visual feedback of the hand was available, TMS over the anterior intraparietal sulcus (aIPS) prolonged reaching time. Our results show for the first time the causal involvement of the posterior mIPS in processing proprioceptive feedback for online reaching control, and demonstrate that distinct cortical areas process proprioceptive-only and multi-sensory information for fast feedback corrections.

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KW - Transcranial magnetic stimulation

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