A high-throughput platform to select for regulators of crispr-cas associated activity

Ruben Vazquez-Uribe (Inventor), Eric Van Der Helm (Inventor), Morten Otto Alexander Sommer (Inventor), Sang Woo Lee (Inventor)

Research output: Patent

74 Downloads (Pure)

Abstract

The invention relates to a method for in vivo detection of small molecules or polypeptides that act as regulators of CRISPR-Cas associated activity, in particular the method is for use in the screening of molecule libraries and non-host DNA libraries. The method employs cells comprising genes expressing CRISPR-Cas associated activity and a reporter protein to allow the detection of said regulators. The invention further relates to cells comprising genes expressing of CRISPR-Cas associated activity and a reporter protein for use in said in vivo screening and detection methods.

Original languageEnglish
IPCC12N 15/ 10 A I
Patent numberWO2019185750
Filing date27/03/2019
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date29/11/2018
Priority numberEP20180209315
Publication statusPublished - 3 Oct 2019

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