A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

Mathias Uhlén, Max J. Karlsson, Wen Zhong, Abdellah Tebani, Christian Pou, Jaromir Mikes, Tadepally Lakshmikanth, Björn Forsström, Fredrik Edfors, Jacob Odeberg, Adil Mardinoglu, Cheng Zhang, Kalle von Feilitzen, Jan Mulder, Evelina Sjöstedt, Andreas Hober, Per Oksvold, Martin Zwahlen, Fredrik Ponten, Cecilia LindskogÅsa Sivertsson, Linn Fagerberg, Petter Brodin

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Abstract

Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.
Original languageEnglish
Article numbereaax9198
JournalScience
Volume366
Issue number6472
ISSN0036-8075
DOIs
Publication statusPublished - 2019

Cite this

Uhlén, M., Karlsson, M. J., Zhong, W., Tebani, A., Pou, C., Mikes, J., Lakshmikanth, T., Forsström, B., Edfors, F., Odeberg, J., Mardinoglu, A., Zhang, C., von Feilitzen, K., Mulder, J., Sjöstedt, E., Hober, A., Oksvold, P., Zwahlen, M., Ponten, F., ... Brodin, P. (2019). A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science, 366(6472), [eaax9198]. https://doi.org/10.1126/science.aax9198