A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

Mathias Uhlén; Max J. Karlsson; Wen Zhong; Abdellah Tebani; Christian Pou; Jaromir Mikes; Tadepally Lakshmikanth; Björn Forsström; Fredrik Edfors; Jacob Odeberg; Adil Mardinoglu; Cheng Zhang; Kalle von Feilitzen; Jan Mulder; Evelina Sjöstedt; Andreas Hober; Per Oksvold; Martin Zwahlen; Fredrik Ponten; Cecilia Lindskog; Åsa Sivertsson; Linn Fagerberg; Petter Brodin

doi:10.1126/science.aax9198

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

Mathias Uhlén, Max J. Karlsson, Wen Zhong, Abdellah Tebani, Christian Pou, Jaromir Mikes, Tadepally Lakshmikanth, Björn Forsström, Fredrik Edfors, Jacob Odeberg, Adil Mardinoglu, Cheng Zhang, Kalle von Feilitzen, Jan Mulder, Evelina Sjöstedt, Andreas Hober, Per Oksvold, Martin Zwahlen, Fredrik Ponten, Cecilia LindskogÅsa Sivertsson, Linn Fagerberg, Petter Brodin

Novo Nordisk Foundation Center for Biosustainability

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.

Original language	English
Article number	eaax9198
Journal	Science
Volume	366
Issue number	6472
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.aax9198
Publication status	Published - 2019

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Uhlén, M., Karlsson, M. J., Zhong, W., Tebani, A., Pou, C., Mikes, J., Lakshmikanth, T., Forsström, B., Edfors, F., Odeberg, J., Mardinoglu, A., Zhang, C., von Feilitzen, K., Mulder, J., Sjöstedt, E., Hober, A., Oksvold, P., Zwahlen, M., Ponten, F., ... Brodin, P. (2019). A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science, 366(6472), Article eaax9198. https://doi.org/10.1126/science.aax9198

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title = "A genome-wide transcriptomic analysis of protein-coding genes in human blood cells",

abstract = "Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.",

author = "Mathias Uhl{\'e}n and Karlsson, {Max J.} and Wen Zhong and Abdellah Tebani and Christian Pou and Jaromir Mikes and Tadepally Lakshmikanth and Bj{\"o}rn Forsstr{\"o}m and Fredrik Edfors and Jacob Odeberg and Adil Mardinoglu and Cheng Zhang and {von Feilitzen}, Kalle and Jan Mulder and Evelina Sj{\"o}stedt and Andreas Hober and Per Oksvold and Martin Zwahlen and Fredrik Ponten and Cecilia Lindskog and {\AA}sa Sivertsson and Linn Fagerberg and Petter Brodin",

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doi = "10.1126/science.aax9198",

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Uhlén, M, Karlsson, MJ, Zhong, W, Tebani, A, Pou, C, Mikes, J, Lakshmikanth, T, Forsström, B, Edfors, F, Odeberg, J, Mardinoglu, A, Zhang, C, von Feilitzen, K, Mulder, J, Sjöstedt, E, Hober, A, Oksvold, P, Zwahlen, M, Ponten, F, Lindskog, C, Sivertsson, Å, Fagerberg, L & Brodin, P 2019, 'A genome-wide transcriptomic analysis of protein-coding genes in human blood cells', Science, vol. 366, no. 6472, eaax9198. https://doi.org/10.1126/science.aax9198

TY - JOUR

T1 - A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

AU - Uhlén, Mathias

AU - Karlsson, Max J.

AU - Zhong, Wen

AU - Tebani, Abdellah

AU - Pou, Christian

AU - Mikes, Jaromir

AU - Lakshmikanth, Tadepally

AU - Forsström, Björn

AU - Edfors, Fredrik

AU - Odeberg, Jacob

AU - Mardinoglu, Adil

AU - Zhang, Cheng

AU - von Feilitzen, Kalle

AU - Mulder, Jan

AU - Sjöstedt, Evelina

AU - Hober, Andreas

AU - Oksvold, Per

AU - Zwahlen, Martin

AU - Ponten, Fredrik

AU - Lindskog, Cecilia

AU - Sivertsson, Åsa

AU - Fagerberg, Linn

AU - Brodin, Petter

PY - 2019

Y1 - 2019

N2 - Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.

AB - Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.

U2 - 10.1126/science.aax9198

DO - 10.1126/science.aax9198

M3 - Journal article

C2 - 31857451

SN - 0036-8075

VL - 366

JO - Science

JF - Science

IS - 6472

M1 - eaax9198

ER -

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

Abstract

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