A genome-wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros; Thomas Folkmann Hansen; David Westergaard; Ioannis Louloudis; Sebastian Kalamajski; Timo Röder; Palle Duun Rohde; Michael Schwinn; Line Harder Clemmensen; Maria Didriksen; Mette Nyegaard; Henrik Hjalgrim; Kaspar René Nielsen; Mie Topholm Bruun; Sisse Rye Ostrowski; Christian Erikstrup; Susan Mikkelsen; Erik Sørensen; Karina Banasik; Jakob Bay; Jens Kjærgaard Boldsen; Thorsten Brodersen; Søren Brunak; Kristoffer Burgdorf; Mona Ameri Chalmer; Maria Didriksen; Khoa Manh Dinh; Joseph Dowsett; Christian Erikstrup; Bjarke Feenstra; Frank Geller; Daniel Gudbjartsson; Thomas Folkmann Hansen; Lotte Hindhede; Henrik Hjalgrim; Rikke Louise Jacobsen; Gregor Jemec; Bitten Aagaard Jensen; Katrine Kaspersen; Bertram Dalskov Kjerulff; Lisette Kogelman; Margit Anita Hørup Larsen; Ioannis Louloudis; Agnete Lundgaard; Susan Mikkelsen; Christina Mikkelsen; Ioanna Nissen; Mette Nyegaard; Sisse Rye Ostrowski; Ole Birger Vestager Pedersen; Alexander Pil Henriksen; Palle Duun Rohde; Klaus Rostgaard; Michael Schwinn; Kari Stefansson; Hreinn Stefánsson; Erik Sørensen; Unnur Thorsteinsdóttir; Lise Wegner Thørner; Mie Topholm Bruun; Henrik Ullum; Thomas Werge; David Westergaard; Ole Birger Vestager Pedersen; Søren Brunak; Karina Banasik; Giuseppe Nicola Giordano

doi:10.1038/s41598-024-51636-0

A genome-wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros, Thomas Folkmann Hansen, David Westergaard, Ioannis Louloudis, Sebastian Kalamajski, Timo Röder, Palle Duun Rohde, Michael Schwinn, Line Harder Clemmensen, Maria Didriksen, Mette Nyegaard, Henrik Hjalgrim, Kaspar René Nielsen, Mie Topholm Bruun, Sisse Rye Ostrowski, Christian Erikstrup, Susan Mikkelsen, Erik Sørensen, Karina Banasik^*, Jakob BayJens Kjærgaard Boldsen, Thorsten Brodersen, Søren Brunak, Kristoffer Burgdorf, Mona Ameri Chalmer, Maria Didriksen, Khoa Manh Dinh, Joseph Dowsett, Christian Erikstrup, Bjarke Feenstra, Frank Geller, Daniel Gudbjartsson, Thomas Folkmann Hansen, Lotte Hindhede, Henrik Hjalgrim, Rikke Louise Jacobsen, Gregor Jemec, Bitten Aagaard Jensen, Katrine Kaspersen, Bertram Dalskov Kjerulff, Lisette Kogelman, Margit Anita Hørup Larsen, Ioannis Louloudis, Agnete Lundgaard, Susan Mikkelsen, Christina Mikkelsen, Ioanna Nissen, Mette Nyegaard, Sisse Rye Ostrowski, Ole Birger Vestager Pedersen, Alexander Pil Henriksen, Palle Duun Rohde, Klaus Rostgaard, Michael Schwinn, Kari Stefansson, Hreinn Stefánsson, Erik Sørensen, Unnur Thorsteinsdóttir, Lise Wegner Thørner, Mie Topholm Bruun, Henrik Ullum, Thomas Werge, David Westergaard, Ole Birger Vestager Pedersen, Søren Brunak, Karina Banasik^*, Giuseppe Nicola Giordano

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

Original language	English
Article number	1402
Journal	Scientific Reports
Volume	14
Issue number	1
Number of pages	12
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-024-51636-0
Publication status	Published - Dec 2024

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Sequeros, C. B., Hansen, T. F., Westergaard, D., Louloudis, I., Kalamajski, S., Röder, T., Rohde, P. D., Schwinn, M., Clemmensen, L. H., Didriksen, M., Nyegaard, M., Hjalgrim, H., Nielsen, K. R., Bruun, M. T., Ostrowski, S. R., Erikstrup, C., Mikkelsen, S., Sørensen, E., Banasik, K., ... Giordano, G. N. (2024). A genome-wide association study of social trust in 33,882 Danish blood donors. Scientific Reports, 14(1), Article 1402. https://doi.org/10.1038/s41598-024-51636-0

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abstract = "Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.",

author = "Sequeros, {Celia Burgos} and Hansen, {Thomas Folkmann} and David Westergaard and Ioannis Louloudis and Sebastian Kalamajski and Timo R{\"o}der and Rohde, {Palle Duun} and Michael Schwinn and Clemmensen, {Line Harder} and Maria Didriksen and Mette Nyegaard and Henrik Hjalgrim and Nielsen, {Kaspar Ren{\'e}} and Bruun, {Mie Topholm} and Ostrowski, {Sisse Rye} and Christian Erikstrup and Susan Mikkelsen and Erik S{\o}rensen and Karina Banasik and Jakob Bay and Boldsen, {Jens Kj{\ae}rgaard} and Thorsten Brodersen and S{\o}ren Brunak and Kristoffer Burgdorf and Chalmer, {Mona Ameri} and Maria Didriksen and Dinh, {Khoa Manh} and Joseph Dowsett and Christian Erikstrup and Bjarke Feenstra and Frank Geller and Daniel Gudbjartsson and Hansen, {Thomas Folkmann} and Lotte Hindhede and Henrik Hjalgrim and Jacobsen, {Rikke Louise} and Gregor Jemec and Jensen, {Bitten Aagaard} and Katrine Kaspersen and Kjerulff, {Bertram Dalskov} and Lisette Kogelman and Larsen, {Margit Anita H{\o}rup} and Ioannis Louloudis and Agnete Lundgaard and Susan Mikkelsen and Christina Mikkelsen and Ioanna Nissen and Mette Nyegaard and Ostrowski, {Sisse Rye} and Pedersen, {Ole Birger Vestager} and {Pil Henriksen}, Alexander and Rohde, {Palle Duun} and Klaus Rostgaard and Michael Schwinn and Kari Stefansson and Hreinn Stef{\'a}nsson and Erik S{\o}rensen and Unnur Thorsteinsd{\'o}ttir and Th{\o}rner, {Lise Wegner} and {Topholm Bruun}, Mie and Henrik Ullum and Thomas Werge and David Westergaard and Pedersen, {Ole Birger Vestager} and S{\o}ren Brunak and Karina Banasik and Giordano, {Giuseppe Nicola}",

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year = "2024",

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doi = "10.1038/s41598-024-51636-0",

language = "English",

volume = "14",

journal = "Scientific Reports",

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Sequeros, CB, Hansen, TF, Westergaard, D, Louloudis, I, Kalamajski, S, Röder, T, Rohde, PD, Schwinn, M, Clemmensen, LH, Didriksen, M, Nyegaard, M, Hjalgrim, H, Nielsen, KR, Bruun, MT, Ostrowski, SR, Erikstrup, C, Mikkelsen, S, Sørensen, E, Banasik, K, Bay, J, Boldsen, JK, Brodersen, T, Brunak, S, Burgdorf, K, Chalmer, MA, Didriksen, M, Dinh, KM, Dowsett, J, Erikstrup, C, Feenstra, B, Geller, F, Gudbjartsson, D, Hansen, TF, Hindhede, L, Hjalgrim, H, Jacobsen, RL, Jemec, G, Jensen, BA, Kaspersen, K, Kjerulff, BD, Kogelman, L, Larsen, MAH, Louloudis, I, Lundgaard, A, Mikkelsen, S, Mikkelsen, C, Nissen, I, Nyegaard, M, Ostrowski, SR, Pedersen, OBV, Pil Henriksen, A, Rohde, PD, Rostgaard, K, Schwinn, M, Stefansson, K, Stefánsson, H, Sørensen, E, Thorsteinsdóttir, U, Thørner, LW, Topholm Bruun, M, Ullum, H, Werge, T, Westergaard, D, Pedersen, OBV, Brunak, S, Banasik, K & Giordano, GN 2024, 'A genome-wide association study of social trust in 33,882 Danish blood donors', Scientific Reports, vol. 14, no. 1, 1402. https://doi.org/10.1038/s41598-024-51636-0

TY - JOUR

T1 - A genome-wide association study of social trust in 33,882 Danish blood donors

AU - Sequeros, Celia Burgos

AU - Hansen, Thomas Folkmann

AU - Westergaard, David

AU - Louloudis, Ioannis

AU - Kalamajski, Sebastian

AU - Röder, Timo

AU - Rohde, Palle Duun

AU - Schwinn, Michael

AU - Clemmensen, Line Harder

AU - Didriksen, Maria

AU - Nyegaard, Mette

AU - Hjalgrim, Henrik

AU - Nielsen, Kaspar René

AU - Bruun, Mie Topholm

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

AU - Mikkelsen, Susan

AU - Sørensen, Erik

AU - Banasik, Karina

AU - Bay, Jakob

AU - Boldsen, Jens Kjærgaard

AU - Brodersen, Thorsten

AU - Brunak, Søren

AU - Burgdorf, Kristoffer

AU - Chalmer, Mona Ameri

AU - Didriksen, Maria

AU - Dinh, Khoa Manh

AU - Dowsett, Joseph

AU - Erikstrup, Christian

AU - Feenstra, Bjarke

AU - Geller, Frank

AU - Gudbjartsson, Daniel

AU - Hansen, Thomas Folkmann

AU - Hindhede, Lotte

AU - Hjalgrim, Henrik

AU - Jacobsen, Rikke Louise

AU - Jemec, Gregor

AU - Jensen, Bitten Aagaard

AU - Kaspersen, Katrine

AU - Kjerulff, Bertram Dalskov

AU - Kogelman, Lisette

AU - Larsen, Margit Anita Hørup

AU - Louloudis, Ioannis

AU - Lundgaard, Agnete

AU - Mikkelsen, Susan

AU - Mikkelsen, Christina

AU - Nissen, Ioanna

AU - Nyegaard, Mette

AU - Ostrowski, Sisse Rye

AU - Pedersen, Ole Birger Vestager

AU - Pil Henriksen, Alexander

AU - Rohde, Palle Duun

AU - Rostgaard, Klaus

AU - Schwinn, Michael

AU - Stefansson, Kari

AU - Stefánsson, Hreinn

AU - Sørensen, Erik

AU - Thorsteinsdóttir, Unnur

AU - Thørner, Lise Wegner

AU - Topholm Bruun, Mie

AU - Ullum, Henrik

AU - Werge, Thomas

AU - Westergaard, David

AU - Pedersen, Ole Birger Vestager

AU - Brunak, Søren

AU - Banasik, Karina

AU - Giordano, Giuseppe Nicola

PY - 2024/12

Y1 - 2024/12

N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

U2 - 10.1038/s41598-024-51636-0

DO - 10.1038/s41598-024-51636-0

M3 - Journal article

C2 - 38228779

AN - SCOPUS:85182480285

SN - 2045-2322

VL - 14

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 1402

ER -

A genome-wide association study of social trust in 33,882 Danish blood donors

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