@inproceedings{7e3408700f624515b354cc106ce927f7,
title = "A generic process template for continuous pharmaceutical production",
abstract = "In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality. To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes). It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.",
keywords = "Process template, API, Substrate adoption, Methodology, Pharmaceutical",
author = "Ravendra Singh and Raquel Rozada-Sanches and William Dean and Jacob Perkins and Frans Muller and Andy Godfrey and Krist Gernaey and Rafiqul Gani and John Woodley",
note = "Presented by John M.Woodley.; 11th International Symposium on Process Systems Engineering, PSE-2012 ; Conference date: 15-07-2012 Through 19-07-2012",
year = "2012",
doi = "10.1016/B978-0-444-59507-2.50135-9",
language = "English",
series = "Computer Aided Chemical Engineering",
publisher = "Elsevier",
pages = "715--719",
editor = "I.A. Karimi and Srinivasan, \{Rajagopalan \}",
booktitle = "Proceedings of the 11th International Symposium on Process Systems Engineering",
address = "United Kingdom",
}