A generic process template for continuous pharmaceutical production

Ravendra Singh, Raquel Rozada-Sanches, William Dean, Jacob Perkins, Frans Muller, Andy Godfrey, Krist Gernaey, Rafiqul Gani, John Woodley

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

280 Downloads (Pure)

Abstract

In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality. To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes). It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.
Original languageEnglish
Title of host publicationProceedings of the 11th International Symposium on Process Systems Engineering
EditorsI.A. Karimi, Rajagopalan Srinivasan
PublisherElsevier
Publication date2012
Pages715-719
DOIs
Publication statusPublished - 2012
Event11th International Symposium on Process Systems Engineering - , Singapore
Duration: 15 Jul 201219 Jul 2012

Conference

Conference11th International Symposium on Process Systems Engineering
Country/TerritorySingapore
Period15/07/201219/07/2012
SeriesComputer Aided Chemical Engineering
Volume31
ISSN1570-7946

Bibliographical note

Presented by John M.Woodley.

Keywords

  • Process template
  • API
  • Substrate adoption
  • Methodology
  • Pharmaceutical

Fingerprint

Dive into the research topics of 'A generic process template for continuous pharmaceutical production'. Together they form a unique fingerprint.

Cite this