Abstract
A generic framework for systematic design of a process monitoring and control system for crystallization processes has been developed in order to obtain the desired end-product properties notably the crystal size distribution (CSD). The design framework contains a generic crystallizer modelling tool-box, a tool for design of operational policies as well as a tool for design of process monitoring and control systems. Through this framework, it is possible for a wide range of crystallization processes to generate the necessary problem-system specific model, the necessary operational policy and a Process Analytical Technology (PAT) system design including implementation of monitoring tools and control strategies in order to produce a desired product with its corresponding target properties. Application of the framework is highlighted through a case study involving the system potassium dihydrogen phosphate (KDP), for which the targeted CSD is defined and achieved in one- and two-dimensional schemes.
Original language | English |
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Title of host publication | Proceedings of the 22nd European Symposium on Computer Aided Process Engineering |
Publication date | 2012 |
Chapter | 5 |
Publication status | Published - 2012 |
Event | 22nd European Symposium on Computer Aided Process Engineering - London, United Kingdom Duration: 17 Jun 2012 → 22 Jun 2012 |
Conference
Conference | 22nd European Symposium on Computer Aided Process Engineering |
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Country/Territory | United Kingdom |
City | London |
Period | 17/06/2012 → 22/06/2012 |
Bibliographical note
Only on CDKeywords
- Crystallization
- Generic crystallization modelling
- Analytical CSD estimator
- Response surface method
- Design of process monitoring and control systems