A Generic Framework for Systematic Design of Process Monitoring and Control System for Crystallization Processes

Noor Asma Fazli Bin Abdul Samad, Kresten Troelstrup Meisler, Gürkan Sin, Krist Gernaey, Rafiqul Gani

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Abstract

A generic framework for systematic design of a process monitoring and control system for crystallization processes has been developed in order to obtain the desired end-product properties notably the crystal size distribution (CSD). The design framework contains a generic crystallizer modelling tool-box, a tool for design of operational policies as well as a tool for design of process monitoring and control systems. Through this framework, it is possible for a wide range of crystallization processes to generate the necessary problem-system specific model, the necessary operational policy and a Process Analytical Technology (PAT) system design including implementation of monitoring tools and control strategies in order to produce a desired product with its corresponding target properties. Application of the framework is highlighted through a case study involving the system potassium dihydrogen phosphate (KDP), for which the targeted CSD is defined and achieved in one- and two-dimensional schemes.
Original languageEnglish
Title of host publicationProceedings of the 22nd European Symposium on Computer Aided Process Engineering
Publication date2012
Chapter5
Publication statusPublished - 2012
Event22nd European Symposium on Computer Aided Process Engineering - London, United Kingdom
Duration: 17 Jun 201222 Jun 2012

Conference

Conference22nd European Symposium on Computer Aided Process Engineering
Country/TerritoryUnited Kingdom
CityLondon
Period17/06/201222/06/2012

Bibliographical note

Only on CD

Keywords

  • Crystallization
  • Generic crystallization modelling
  • Analytical CSD estimator
  • Response surface method
  • Design of process monitoring and control systems

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