A generative model for segmentation of tumor and organs-at-risk for radiation therapy planning of glioblastoma patients

Mikael Agn, Ian Law, Per Munck Af Rosenschöld, Koen Van Leemput

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Abstract

We present a fully automated generative method for simultaneous brain tumor and organs-at-risk segmentation in multi-modal magnetic resonance images. The method combines an existing whole-brain segmentation technique with a spatial tumor prior, which uses convolutional restricted Boltzmann machines to model tumor shape. The method is not tuned to any specific imaging protocol and can simultaneously segment the gross tumor volume, peritumoral edema and healthy tissue structures relevant for radiotherapy planning. We validate the method on a manually delineated clinical data set of glioblastoma patients by comparing segmentations of gross tumor volume, brainstem and hippocampus. The preliminary results demonstrate the feasibility of the method.
Original languageEnglish
Title of host publicationSPIE Medical Imaging 2016: Image Processing
Number of pages9
Volume9784
PublisherSPIE - International Society for Optical Engineering
Publication date2016
Article number97841D
DOIs
Publication statusPublished - 2016
EventSPIE Medical Imaging 2016: Image Processing - San Diego, United States
Duration: 27 Feb 20163 Mar 2016
Conference number: 9784

Conference

ConferenceSPIE Medical Imaging 2016
Number9784
CountryUnited States
CitySan Diego
Period27/02/201603/03/2016
SeriesProceedings of SPIE, the International Society for Optical Engineering
Volume9784
ISSN0277-786X

Bibliographical note

Copyright 2016 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

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