A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice

J. H. Allen; M. Utley; H. Van den Bosch; P. Nuijten; M. Witvliet; B. A. McCormick; K. A. Krogfelt; Tine Rask Licht; D. Brown; M. Mauel; M. P. Leatham; D. C. Laux; P. S. Cohen

A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice

J. H. Allen, M. Utley, H. Van den Bosch, P. Nuijten, M. Witvliet, B. A. McCormick, K. A. Krogfelt, Tine Rask Licht, D. Brown, M. Mauel, M. P. Leatham, D. C. Laux, P. S. Cohen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, evidence is presented that the mutation in SR-11 Fad(-) that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

Original language	English
Journal	Infection and Immunity
Volume	68
Issue number	6
Pages (from-to)	3772-3775
ISSN	0019-9567
Publication status	Published - 2000

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@article{81c9a4b0ab424a91a8ab84d3a97d5097,

title = "A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice",

abstract = "A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, evidence is presented that the mutation in SR-11 Fad(-) that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.",

author = "Allen, {J. H.} and M. Utley and {Van den Bosch}, H. and P. Nuijten and M. Witvliet and McCormick, {B. A.} and Krogfelt, {K. A.} and Licht, {Tine Rask} and D. Brown and M. Mauel and Leatham, {M. P.} and Laux, {D. C.} and Cohen, {P. S.}",

year = "2000",

language = "English",

volume = "68",

pages = "3772--3775",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "6",

}

TY - JOUR

T1 - A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice

AU - Allen, J. H.

AU - Utley, M.

AU - Van den Bosch, H.

AU - Nuijten, P.

AU - Witvliet, M.

AU - McCormick, B. A.

AU - Krogfelt, K. A.

AU - Licht, Tine Rask

AU - Brown, D.

AU - Mauel, M.

AU - Leatham, M. P.

AU - Laux, D. C.

AU - Cohen, P. S.

PY - 2000

Y1 - 2000

N2 - A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, evidence is presented that the mutation in SR-11 Fad(-) that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

AB - A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, evidence is presented that the mutation in SR-11 Fad(-) that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

M3 - Journal article

SN - 0019-9567

VL - 68

SP - 3772

EP - 3775

JO - Infection and Immunity

JF - Infection and Immunity

IS - 6

ER -

A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice

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