A family of multicyclic indolosesquiterpenes from a bacterial endophyte

Ling Ding; Armin Maier; Heinz-Herbert Fiebig; Wen-Han Lin; Christian Hertweck

doi:10.1039/c1ob05283g

A family of multicyclic indolosesquiterpenes from a bacterial endophyte

Ling Ding
, Armin Maier
, Heinz-Herbert Fiebig
, Wen-Han Lin
, Christian Hertweck

Research output: Contribution to journal › Journal article › Communication

Abstract

Three novel indolosesquiterpenes, xiamycin B (1b), indosespene (2), and sespenine (3), along with the known xiamycin A (1a) were isolated from the culture broth of Streptomyces sp. HKI0595, a bacterial endophyte of the widespread mangrove tree Kandelia candel. Agar diffusion assays revealed moderate to strong antimicrobial activities against several bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, while no cytotoxicity against human tumor cell lines was observed. Together with the previously reported oridamycin, the endophyte metabolites represent the first indolosesquiterpenes isolated from prokaryotes.

Original language	English
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	11
Pages (from-to)	4029-4031
Number of pages	3
ISSN	1477-0520
DOIs	https://doi.org/10.1039/c1ob05283g
Publication status	Published - 2011
Externally published	Yes

Keywords

Chemistry

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title = "A family of multicyclic indolosesquiterpenes from a bacterial endophyte",

abstract = "Three novel indolosesquiterpenes, xiamycin B (1b), indosespene (2), and sespenine (3), along with the known xiamycin A (1a) were isolated from the culture broth of Streptomyces sp. HKI0595, a bacterial endophyte of the widespread mangrove tree Kandelia candel. Agar diffusion assays revealed moderate to strong antimicrobial activities against several bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, while no cytotoxicity against human tumor cell lines was observed. Together with the previously reported oridamycin, the endophyte metabolites represent the first indolosesquiterpenes isolated from prokaryotes.",

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doi = "10.1039/c1ob05283g",

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T1 - A family of multicyclic indolosesquiterpenes from a bacterial endophyte

AU - Ding, Ling

AU - Maier, Armin

AU - Fiebig, Heinz-Herbert

AU - Lin, Wen-Han

AU - Hertweck, Christian

PY - 2011

Y1 - 2011

N2 - Three novel indolosesquiterpenes, xiamycin B (1b), indosespene (2), and sespenine (3), along with the known xiamycin A (1a) were isolated from the culture broth of Streptomyces sp. HKI0595, a bacterial endophyte of the widespread mangrove tree Kandelia candel. Agar diffusion assays revealed moderate to strong antimicrobial activities against several bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, while no cytotoxicity against human tumor cell lines was observed. Together with the previously reported oridamycin, the endophyte metabolites represent the first indolosesquiterpenes isolated from prokaryotes.

AB - Three novel indolosesquiterpenes, xiamycin B (1b), indosespene (2), and sespenine (3), along with the known xiamycin A (1a) were isolated from the culture broth of Streptomyces sp. HKI0595, a bacterial endophyte of the widespread mangrove tree Kandelia candel. Agar diffusion assays revealed moderate to strong antimicrobial activities against several bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, while no cytotoxicity against human tumor cell lines was observed. Together with the previously reported oridamycin, the endophyte metabolites represent the first indolosesquiterpenes isolated from prokaryotes.

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U2 - 10.1039/c1ob05283g

DO - 10.1039/c1ob05283g

M3 - Journal article

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VL - 9

SP - 4029

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 11

ER -

A family of multicyclic indolosesquiterpenes from a bacterial endophyte

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