A family of microbial lysine transporter polypeptides

Sailesh Malla; Morten Otto Alexander Sommer; Eric van der Helm; Stefan Wieschalka; Jochen Förster

A family of microbial lysine transporter polypeptides

Sailesh Malla (Inventor)
, Morten Otto Alexander Sommer (Inventor)
, Eric van der Helm (Inventor)
, Stefan Wieschalka (Inventor)
, Jochen Förster (Inventor)

Research output: Patent

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Abstract

The present invention provides a genetically modified microbial cell for production of lysine, comprising a transgene encoding a polypeptide capable of exporting lysine from the cell. The genetically modified microbial cell for production of lysine may be further characterized by genetic modifications that confer reduced lysine metabolism and/or enhanced lysine synthesis as compared to the parent cell from which said genetically modified cell was derived. The invention further provides a method for producing lysine using the genetically modified microbial cell. The invention further provides a novel family of lysine transporter polypeptides; and the use of said polypeptide to enhance production of extracellular lysine in a microbial cell.

Original language	English
IPC	C12P 13/ 08 A I
Patent number	WO2017085241
Filing date	26/05/2017
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	19/11/2015
Priority number	EP20150195401
Publication status	Published - 26 May 2017

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title = "A family of microbial lysine transporter polypeptides",

abstract = "The present invention provides a genetically modified microbial cell for production of lysine, comprising a transgene encoding a polypeptide capable of exporting lysine from the cell. The genetically modified microbial cell for production of lysine may be further characterized by genetic modifications that confer reduced lysine metabolism and/or enhanced lysine synthesis as compared to the parent cell from which said genetically modified cell was derived. The invention further provides a method for producing lysine using the genetically modified microbial cell. The invention further provides a novel family of lysine transporter polypeptides; and the use of said polypeptide to enhance production of extracellular lysine in a microbial cell.",

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T1 - A family of microbial lysine transporter polypeptides

AU - Malla, Sailesh

AU - Sommer, Morten Otto Alexander

AU - van der Helm, Eric

AU - Wieschalka, Stefan

AU - Förster, Jochen

PY - 2017/5/26

Y1 - 2017/5/26

N2 - The present invention provides a genetically modified microbial cell for production of lysine, comprising a transgene encoding a polypeptide capable of exporting lysine from the cell. The genetically modified microbial cell for production of lysine may be further characterized by genetic modifications that confer reduced lysine metabolism and/or enhanced lysine synthesis as compared to the parent cell from which said genetically modified cell was derived. The invention further provides a method for producing lysine using the genetically modified microbial cell. The invention further provides a novel family of lysine transporter polypeptides; and the use of said polypeptide to enhance production of extracellular lysine in a microbial cell.

AB - The present invention provides a genetically modified microbial cell for production of lysine, comprising a transgene encoding a polypeptide capable of exporting lysine from the cell. The genetically modified microbial cell for production of lysine may be further characterized by genetic modifications that confer reduced lysine metabolism and/or enhanced lysine synthesis as compared to the parent cell from which said genetically modified cell was derived. The invention further provides a method for producing lysine using the genetically modified microbial cell. The invention further provides a novel family of lysine transporter polypeptides; and the use of said polypeptide to enhance production of extracellular lysine in a microbial cell.

M3 - Patent

M1 - WO2017085241

Y2 - 2017/05/26

ER -

A family of microbial lysine transporter polypeptides

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