A family of microbial lysine transporter polypeptides

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The present invention provides a genetically modified microbial cell for production of lysine, comprising a transgene encoding a polypeptide capable of exporting lysine from the cell. The genetically modified microbial cell for production of lysine may be further characterized by genetic modifications that confer reduced lysine metabolism and/or enhanced lysine synthesis as compared to the parent cell from which said genetically modified cell was derived. The invention further provides a method for producing lysine using the genetically modified microbial cell. The invention further provides a novel family of lysine transporter polypeptides; and the use of said polypeptide to enhance production of extracellular lysine in a microbial cell.

Original languageEnglish
IPCC12P 13/ 08 A I
Patent numberWO2017085241
Filing date26/05/2017
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date19/11/2015
Priority numberEP20150195401
Publication statusPublished - 26 May 2017

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