Abstract
The present invention provides a genetically modified microbial cell for production of lysine, comprising a transgene encoding a polypeptide capable of exporting lysine from the cell. The genetically modified microbial cell for production of lysine may be further characterized by genetic modifications that confer reduced lysine metabolism and/or enhanced lysine synthesis as compared to the parent cell from which said genetically modified cell was derived. The invention further provides a method for producing lysine using the genetically modified microbial cell. The invention further provides a novel family of lysine transporter polypeptides; and the use of said polypeptide to enhance production of extracellular lysine in a microbial cell.
Original language | English |
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IPC | C12P 13/ 08 A I |
Patent number | WO2017085241 |
Filing date | 26/05/2017 |
Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
Priority date | 19/11/2015 |
Priority number | EP20150195401 |
Publication status | Published - 26 May 2017 |