A facile and efficient synthesis of (+)- and (-)-allo-muscarine and analogs

Jens Chr. Norrild, Christian Pedersen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Treatment of easily obtainable 1-alkylamino-1,3,6-trideoxyhexitols with hydrogen fluoride in the presence of formic acid gives the corresponding C-5 inverted 2,5-anhydrides in high yields. The synthesis of allo-muscarine and its N-benzyl analog from galactono-1,4-lactone is reported in 30 and 41% overall yield, respectively.
    Original languageEnglish
    JournalSynthesis
    Issue number10
    Pages (from-to)1127-1128
    ISSN0039-7881
    Publication statusPublished - 1997

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