A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.

D. M. Mutch; Tune Hannes Pers; M. R. Temanni; V. Pelloux; A. Marquez-Quinones; C. Holst; Jose Ignacio Martinez; D. Babalis; M. A. van Baak; T. Handjieva-Darlenska; C. G. Walker; A. Astrup; W. H. M. Saris; D. Langin; N. Viguerie; J. D. Zucker; K. Clement; DiOGenes Project

doi:10.3945/ajcn.110.006858

A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.

D. M. Mutch, Tune Hannes Pers, M. R. Temanni, V. Pelloux, A. Marquez-Quinones, C. Holst, Jose Ignacio Martinez, D. Babalis, M. A. van Baak, T. Handjieva-Darlenska, C. G. Walker, A. Astrup, W. H. M. Saris, D. Langin, N. Viguerie, J. D. Zucker, K. Clement, DiOGenes Project

Department of Chemical and Biochemical Engineering

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background: Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge. Objective: The present study was designed to assess whether changes in subcutaneous adipose tissue (scAT) gene expression during a low-calorie diet (LCD) could be used to differentiate and predict subjects who experience successful short-term weight maintenance from subjects who experience weight regain. Design: Forty white women followed a dietary protocol consisting of an 8-wk LCD phase followed by a 6-mo weight-maintenance phase. Participants were classified as weight maintainers (WMs; 0–10% weight regain) and weight regainers (WRs; 50–100% weight regain) by considering changes in body weight during the 2 phases. Anthropometric measurements, bioclinical variables, and scAT gene expression were studied in all individuals before and after the LCD. Energy intake was estimated by using 3-d dietary records. Results: No differences in body weight and fasting insulin were observed between WMs and WRs at baseline or after the LCD period. The LCD resulted in significant decreases in body weight and in several plasma variables in both groups. WMs experienced a significant reduction in insulin secretion in response to an oral-glucose-tolerance test after the LCD; in contrast, no changes in insulin secretion were observed in WRs after the LCD. An ANOVA of scAT gene expression showed that genes regulating fatty acid metabolism, citric acid cycle, oxidative phosphorylation, and apoptosis were regulated differently by the LCD in WM and WR subjects. Conclusion: This study suggests that LCD-induced changes in insulin secretion and scAT gene expression may have the potential to predict successful short-term weight maintenance. This trial was registered at clinicaltrials.gov as NCT00390637. ©American Society for Nutrition. All rights reserved.

Original language	English
Journal	American Journal of Clinical Nutrition
Volume	94
Issue number	6
Pages (from-to)	1399-1409
ISSN	0002-9165
DOIs	https://doi.org/10.3945/ajcn.110.006858
Publication status	Published - 2011

Keywords

ADIPOSE TISSUES
ANTHROPOMETRIC PARAMETERS
BODY WT.
CALORIES
CALORIES LOW DIET
DIET
GENE EXPRESSION
POPULATION GROUPS
THERAPY
WOMEN
WT. LOSS DIET

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mutch, D. M., Pers, T. H., Temanni, M. R., Pelloux, V., Marquez-Quinones, A., Holst, C., Martinez, J. I., Babalis, D., Baak, M. A. V., Handjieva-Darlenska, T., Walker, C. G., Astrup, A., Saris, W. H. M., Langin, D., Viguerie, N., Zucker, J. D., Clement, K., & DiOGenes Project (2011). A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects. American Journal of Clinical Nutrition, 94(6), 1399-1409. https://doi.org/10.3945/ajcn.110.006858

@article{41e3f232e3f9424d8c83fac805f23a26,

title = "A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.",

abstract = "Background: Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge. Objective: The present study was designed to assess whether changes in subcutaneous adipose tissue (scAT) gene expression during a low-calorie diet (LCD) could be used to differentiate and predict subjects who experience successful short-term weight maintenance from subjects who experience weight regain. Design: Forty white women followed a dietary protocol consisting of an 8-wk LCD phase followed by a 6-mo weight-maintenance phase. Participants were classified as weight maintainers (WMs; 0–10% weight regain) and weight regainers (WRs; 50–100% weight regain) by considering changes in body weight during the 2 phases. Anthropometric measurements, bioclinical variables, and scAT gene expression were studied in all individuals before and after the LCD. Energy intake was estimated by using 3-d dietary records. Results: No differences in body weight and fasting insulin were observed between WMs and WRs at baseline or after the LCD period. The LCD resulted in significant decreases in body weight and in several plasma variables in both groups. WMs experienced a significant reduction in insulin secretion in response to an oral-glucose-tolerance test after the LCD; in contrast, no changes in insulin secretion were observed in WRs after the LCD. An ANOVA of scAT gene expression showed that genes regulating fatty acid metabolism, citric acid cycle, oxidative phosphorylation, and apoptosis were regulated differently by the LCD in WM and WR subjects. Conclusion: This study suggests that LCD-induced changes in insulin secretion and scAT gene expression may have the potential to predict successful short-term weight maintenance. This trial was registered at clinicaltrials.gov as NCT00390637. {\textcopyright}American Society for Nutrition. All rights reserved.",

keywords = "ADIPOSE TISSUES, ANTHROPOMETRIC PARAMETERS, BODY WT., CALORIES, CALORIES LOW DIET, DIET, GENE EXPRESSION, POPULATION GROUPS, THERAPY, WOMEN, WT. LOSS DIET",

author = "Mutch, {D. M.} and Pers, {Tune Hannes} and Temanni, {M. R.} and V. Pelloux and A. Marquez-Quinones and C. Holst and Martinez, {Jose Ignacio} and D. Babalis and Baak, {M. A. van} and T. Handjieva-Darlenska and Walker, {C. G.} and A. Astrup and Saris, {W. H. M.} and D. Langin and N. Viguerie and Zucker, {J. D.} and K. Clement and {DiOGenes Project}",

year = "2011",

doi = "10.3945/ajcn.110.006858",

language = "English",

volume = "94",

pages = "1399--1409",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "6",

}

Mutch, DM, Pers, TH, Temanni, MR, Pelloux, V, Marquez-Quinones, A, Holst, C, Martinez, JI, Babalis, D, Baak, MAV, Handjieva-Darlenska, T, Walker, CG, Astrup, A, Saris, WHM, Langin, D, Viguerie, N, Zucker, JD, Clement, K & DiOGenes Project 2011, 'A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.', American Journal of Clinical Nutrition, vol. 94, no. 6, pp. 1399-1409. https://doi.org/10.3945/ajcn.110.006858

TY - JOUR

T1 - A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.

AU - Mutch, D. M.

AU - Pers, Tune Hannes

AU - Temanni, M. R.

AU - Pelloux, V.

AU - Marquez-Quinones, A.

AU - Holst, C.

AU - Martinez, Jose Ignacio

AU - Babalis, D.

AU - Baak, M. A. van

AU - Handjieva-Darlenska, T.

AU - Walker, C. G.

AU - Astrup, A.

AU - Saris, W. H. M.

AU - Langin, D.

AU - Viguerie, N.

AU - Zucker, J. D.

AU - Clement, K.

AU - DiOGenes Project,

PY - 2011

Y1 - 2011

N2 - Background: Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge. Objective: The present study was designed to assess whether changes in subcutaneous adipose tissue (scAT) gene expression during a low-calorie diet (LCD) could be used to differentiate and predict subjects who experience successful short-term weight maintenance from subjects who experience weight regain. Design: Forty white women followed a dietary protocol consisting of an 8-wk LCD phase followed by a 6-mo weight-maintenance phase. Participants were classified as weight maintainers (WMs; 0–10% weight regain) and weight regainers (WRs; 50–100% weight regain) by considering changes in body weight during the 2 phases. Anthropometric measurements, bioclinical variables, and scAT gene expression were studied in all individuals before and after the LCD. Energy intake was estimated by using 3-d dietary records. Results: No differences in body weight and fasting insulin were observed between WMs and WRs at baseline or after the LCD period. The LCD resulted in significant decreases in body weight and in several plasma variables in both groups. WMs experienced a significant reduction in insulin secretion in response to an oral-glucose-tolerance test after the LCD; in contrast, no changes in insulin secretion were observed in WRs after the LCD. An ANOVA of scAT gene expression showed that genes regulating fatty acid metabolism, citric acid cycle, oxidative phosphorylation, and apoptosis were regulated differently by the LCD in WM and WR subjects. Conclusion: This study suggests that LCD-induced changes in insulin secretion and scAT gene expression may have the potential to predict successful short-term weight maintenance. This trial was registered at clinicaltrials.gov as NCT00390637. ©American Society for Nutrition. All rights reserved.

AB - Background: Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge. Objective: The present study was designed to assess whether changes in subcutaneous adipose tissue (scAT) gene expression during a low-calorie diet (LCD) could be used to differentiate and predict subjects who experience successful short-term weight maintenance from subjects who experience weight regain. Design: Forty white women followed a dietary protocol consisting of an 8-wk LCD phase followed by a 6-mo weight-maintenance phase. Participants were classified as weight maintainers (WMs; 0–10% weight regain) and weight regainers (WRs; 50–100% weight regain) by considering changes in body weight during the 2 phases. Anthropometric measurements, bioclinical variables, and scAT gene expression were studied in all individuals before and after the LCD. Energy intake was estimated by using 3-d dietary records. Results: No differences in body weight and fasting insulin were observed between WMs and WRs at baseline or after the LCD period. The LCD resulted in significant decreases in body weight and in several plasma variables in both groups. WMs experienced a significant reduction in insulin secretion in response to an oral-glucose-tolerance test after the LCD; in contrast, no changes in insulin secretion were observed in WRs after the LCD. An ANOVA of scAT gene expression showed that genes regulating fatty acid metabolism, citric acid cycle, oxidative phosphorylation, and apoptosis were regulated differently by the LCD in WM and WR subjects. Conclusion: This study suggests that LCD-induced changes in insulin secretion and scAT gene expression may have the potential to predict successful short-term weight maintenance. This trial was registered at clinicaltrials.gov as NCT00390637. ©American Society for Nutrition. All rights reserved.

KW - ADIPOSE TISSUES

KW - ANTHROPOMETRIC PARAMETERS

KW - BODY WT.

KW - CALORIES

KW - CALORIES LOW DIET

KW - DIET

KW - GENE EXPRESSION

KW - POPULATION GROUPS

KW - THERAPY

KW - WOMEN

KW - WT. LOSS DIET

U2 - 10.3945/ajcn.110.006858

DO - 10.3945/ajcn.110.006858

M3 - Journal article

SN - 0002-9165

VL - 94

SP - 1399

EP - 1409

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 6

ER -

A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.

Abstract

Keywords

UN SDGs

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