A contribution to the systematization of bovine herpesvirus 1 based on genomic mapping by restriction fragment pattern analysis

Laurids Siig Christensen, K.G. Madsen, B. Nylin, L. Rønsholt

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Fourteen isolates of bovine herpesvirus 1 (BHV-1) found representative of more than 100 isolates studied, were compared by restriction fragment pattern analyses and molecularly characterized. A number of evolutionary links between the variants originally associated with infectious bovine rhinotracheitis and the variants originally associated with infectious pustular vulvovaginitis were identified. These findings, as well as the lack of any correlation between genome type and clinical manifestation, confirm that there is no phylogenetic basis for a distinction between groups of strains associated with genital and respiratory disease. Two attenuated vaccine strains can be identified as deviating from field isolates.
Original languageEnglish
JournalVirus Research
Volume46
Issue number1-2
Pages (from-to)177-182
ISSN0168-1702
DOIs
Publication statusPublished - 1996
Externally publishedYes

Keywords

  • Bovine herpesvirus 1
  • Restriction fragment pattern analysis
  • Vaccine

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