TY - JOUR
T1 - A comprehensive review on microbial hyaluronan-degrading enzymes
T2 - from virulence factors to biotechnological tools
AU - Jiang, Jia Yu
AU - Xue, Dai
AU - Gong, Jin Song
AU - Zheng, Qin Xin
AU - Zhang, Yue Sheng
AU - Su, Chang
AU - Xu, Zheng Hong
AU - Shi, Jin Song
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2025
Y1 - 2025
N2 - Hyaluronan (HA), a natural high molecular weight polysaccharide, has extensive applications in cosmetology and medical treatment. Hyaluronan-degrading enzymes (Hyals) act as molecular scissors that cleave HA by breaking the glucosidic linkage. Hyals are present in diverse organisms, including vertebrates, invertebrates and microorganisms, and play momentous roles in biological processes. In recent years, microbial Hyals (mHyals) have gained considerable attention for their exceptional performance in the production and processing of HA. Moreover, the applications of mHyals have been greatly extended to various biomedical fields. To explore the potential applications of mHyals, a thorough comprehension is imperative. In this context, this review systematically summarizes the sources, structures, mechanisms and enzymatic properties of mHyals and discusses their biological functions in host invasion, disease development, and regulation of intestinal flora. Furthermore, versatile applications inspired by their biological functions in medicine development, molecular biology, and industrial biotechnology are comprehensively reviewed. Finally, prospects are presented to emphasize the importance of exploration, expression and characterization of mHyals and the necessity of excavating their potential in biotechnological fields.
AB - Hyaluronan (HA), a natural high molecular weight polysaccharide, has extensive applications in cosmetology and medical treatment. Hyaluronan-degrading enzymes (Hyals) act as molecular scissors that cleave HA by breaking the glucosidic linkage. Hyals are present in diverse organisms, including vertebrates, invertebrates and microorganisms, and play momentous roles in biological processes. In recent years, microbial Hyals (mHyals) have gained considerable attention for their exceptional performance in the production and processing of HA. Moreover, the applications of mHyals have been greatly extended to various biomedical fields. To explore the potential applications of mHyals, a thorough comprehension is imperative. In this context, this review systematically summarizes the sources, structures, mechanisms and enzymatic properties of mHyals and discusses their biological functions in host invasion, disease development, and regulation of intestinal flora. Furthermore, versatile applications inspired by their biological functions in medicine development, molecular biology, and industrial biotechnology are comprehensively reviewed. Finally, prospects are presented to emphasize the importance of exploration, expression and characterization of mHyals and the necessity of excavating their potential in biotechnological fields.
KW - Anti-bacteria
KW - Cancer therapy
KW - Disease development
KW - Host invasion
KW - Hyaluronan degradation
KW - Hyaluronan detection
KW - Hyaluronan lyase
KW - Hyaluronan-degrading enzymes
KW - Hyaluronidase
U2 - 10.1186/s40643-024-00832-x
DO - 10.1186/s40643-024-00832-x
M3 - Review
C2 - 39722064
AN - SCOPUS:85212923912
SN - 2197-4365
VL - 11
JO - Bioresources and Bioprocessing
JF - Bioresources and Bioprocessing
IS - 1
M1 - 114
ER -