A comprehensive metabolic map for production of bio-based chemicals

Research output: Contribution to journalReview – Annual report year: 2019Researchpeer-review

  • Author: Lee, Sang Yup

    New Bioactive Compounds, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Kim, Hyun Uk

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Chae, Tong Un

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Cho, Jae Sung

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Kim, Je Woong

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Shin, Jae Ho

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Kim, Dong In

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Ko, Yoo Sung

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Jang, Woo Dae

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

  • Author: Jang, Yu Sin

    Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of

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Production of industrial chemicals using renewable biomass feedstock is becoming increasingly important to address limited fossil resources, climate change and other environmental problems. To develop high-performance microbial cell factories, equivalent to chemical plants, microorganisms undergo systematic metabolic engineering to efficiently convert biomass-derived carbon sources into target chemicals. Over the past two decades, many engineered microorganisms capable of producing natural and non-natural chemicals have been developed. This Review details the current status of representative industrial chemicals that are produced through biological and/or chemical reactions. We present a comprehensive bio-based chemicals map that highlights the strategies and pathways of single or multiple biological reactions, chemical reactions and combinations thereof towards production of particular chemicals of interest. Future challenges are also discussed to enable production of even more diverse chemicals and more efficient production of chemicals from renewable feedstocks.

Original languageEnglish
JournalNature Catalysis
Volume2
Issue number1
Pages (from-to)18-33
Number of pages16
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

ID: 169147423