Abstract
Production of industrial chemicals using renewable biomass feedstock is becoming increasingly important to address limited fossil resources, climate change and other environmental problems. To develop high-performance microbial cell factories, equivalent to chemical plants, microorganisms undergo systematic metabolic engineering to efficiently convert biomass-derived carbon sources into target chemicals. Over the past two decades, many engineered microorganisms capable of producing natural and non-natural chemicals have been developed. This Review details the current status of representative industrial chemicals that are produced through biological and/or chemical reactions. We present a comprehensive bio-based chemicals map that highlights the strategies and pathways of single or multiple biological reactions, chemical reactions and combinations thereof towards production of particular chemicals of interest. Future challenges are also discussed to enable production of even more diverse chemicals and more efficient production of chemicals from renewable feedstocks.
| Original language | English |
|---|---|
| Journal | Nature Catalysis |
| Volume | 2 |
| Issue number | 1 |
| Pages (from-to) | 18-33 |
| Number of pages | 16 |
| DOIs | |
| Publication status | Published - 2019 |
Cite this
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A comprehensive metabolic map for production of bio-based chemicals. / Lee, Sang Yup; Kim, Hyun Uk; Chae, Tong Un; Cho, Jae Sung; Kim, Je Woong; Shin, Jae Ho; Kim, Dong In; Ko, Yoo Sung; Jang, Woo Dae; Jang, Yu Sin.
In: Nature Catalysis, Vol. 2, No. 1, 2019, p. 18-33.Research output: Contribution to journal › Review › Research › peer-review
TY - JOUR
T1 - A comprehensive metabolic map for production of bio-based chemicals
AU - Lee, Sang Yup
AU - Kim, Hyun Uk
AU - Chae, Tong Un
AU - Cho, Jae Sung
AU - Kim, Je Woong
AU - Shin, Jae Ho
AU - Kim, Dong In
AU - Ko, Yoo Sung
AU - Jang, Woo Dae
AU - Jang, Yu Sin
PY - 2019
Y1 - 2019
N2 - Production of industrial chemicals using renewable biomass feedstock is becoming increasingly important to address limited fossil resources, climate change and other environmental problems. To develop high-performance microbial cell factories, equivalent to chemical plants, microorganisms undergo systematic metabolic engineering to efficiently convert biomass-derived carbon sources into target chemicals. Over the past two decades, many engineered microorganisms capable of producing natural and non-natural chemicals have been developed. This Review details the current status of representative industrial chemicals that are produced through biological and/or chemical reactions. We present a comprehensive bio-based chemicals map that highlights the strategies and pathways of single or multiple biological reactions, chemical reactions and combinations thereof towards production of particular chemicals of interest. Future challenges are also discussed to enable production of even more diverse chemicals and more efficient production of chemicals from renewable feedstocks.
AB - Production of industrial chemicals using renewable biomass feedstock is becoming increasingly important to address limited fossil resources, climate change and other environmental problems. To develop high-performance microbial cell factories, equivalent to chemical plants, microorganisms undergo systematic metabolic engineering to efficiently convert biomass-derived carbon sources into target chemicals. Over the past two decades, many engineered microorganisms capable of producing natural and non-natural chemicals have been developed. This Review details the current status of representative industrial chemicals that are produced through biological and/or chemical reactions. We present a comprehensive bio-based chemicals map that highlights the strategies and pathways of single or multiple biological reactions, chemical reactions and combinations thereof towards production of particular chemicals of interest. Future challenges are also discussed to enable production of even more diverse chemicals and more efficient production of chemicals from renewable feedstocks.
U2 - 10.1038/s41929-018-0212-4
DO - 10.1038/s41929-018-0212-4
M3 - Review
VL - 2
SP - 18
EP - 33
JO - Nature Catalysis
JF - Nature Catalysis
SN - 2520-1158
IS - 1
ER -