TY - JOUR
T1 - A comprehensive and systemic review of ginseng-based nanomaterials
T2 - Synthesis, targeted delivery, and biomedical applications
AU - Balusamy, Sri Renukadevi
AU - Perumalsamy, Haribalan
AU - Huq, Md Amdadul
AU - Yoon, Tae Hyun
AU - Mijakovic, Ivan
AU - Thangavelu, Lakshmi
AU - Yang, Deok Chun
AU - Rahimi, Shadi
N1 - Publisher Copyright:
© 2023 The Authors. Medicinal Research Reviews published by Wiley Periodicals LLC.
PY - 2023
Y1 - 2023
N2 - Among 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chinese ginseng) are highly recognized for the presence of bioactive compound, ginsenosides and their pharmacological effects. P. ginseng is widely used for synthesis of different types of nanoparticles compared to P. quinquefolius and P. notoginseng. The use of nano-ginseng could increase the oral bioavailability, membrane permeability, and thus provide effective delivery of ginsenosides to the target sites through transport system. In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications. Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites. Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.
AB - Among 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chinese ginseng) are highly recognized for the presence of bioactive compound, ginsenosides and their pharmacological effects. P. ginseng is widely used for synthesis of different types of nanoparticles compared to P. quinquefolius and P. notoginseng. The use of nano-ginseng could increase the oral bioavailability, membrane permeability, and thus provide effective delivery of ginsenosides to the target sites through transport system. In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications. Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites. Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.
KW - Biomedical applications
KW - Ginseng nanoparticle synthesis
KW - Ginsenoside based nanoparticles
KW - Green synthesis
KW - Microbial synthesis
KW - Panax species
KW - Polymer-based ginsenoside nanocarrier
KW - Targeted delivery
U2 - 10.1002/med.21953
DO - 10.1002/med.21953
M3 - Review
C2 - 36939049
AN - SCOPUS:85150828341
SN - 0198-6325
VL - 43
JO - Medicinal Research Reviews
JF - Medicinal Research Reviews
IS - 5
ER -