Abstract
| Original language | English |
|---|---|
| Title of host publication | Therapeutic Laser Applications and Laser-Tissue Interactions IV : Proceedings of SPIE |
| Volume | Vol. 7373 |
| Publication date | 2009 |
| DOIs | |
| Publication status | Published - 2009 |
| Event | Fiber Lasers VII: Technology, Systems and Applications : Therapeutic Laser Applications and Laser-Tissue Interactions - San Francisco, CA, United States Duration: 23 Jan 2010 → 28 Jan 2010 Conference number: 7 |
Conference
| Conference | Fiber Lasers VII: Technology, Systems and Applications |
|---|---|
| Number | 7 |
| Country | United States |
| City | San Francisco, CA |
| Period | 23/01/2010 → 28/01/2010 |
| Other | SPIE volume 7580 |
Keywords
- semi{coupled PDEs
- water contrast
- LITT
- liver metastasis
Cite this
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A Combined Mathematical-Physical Model of Laser-Induced Thermotherapy (LITT). / Enevoldsen, Marie Sand; Skovgaard, Ove; Andersen, Peter E.
Therapeutic Laser Applications and Laser-Tissue Interactions IV: Proceedings of SPIE. Vol. Vol. 7373 2009.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
TY - GEN
T1 - A Combined Mathematical-Physical Model of Laser-Induced Thermotherapy (LITT)
AU - Enevoldsen, Marie Sand
AU - Skovgaard, Ove
AU - Andersen, Peter E.
PY - 2009
Y1 - 2009
N2 - Laser{induced thermo therapy (LITT) is an alternative, gentle therapy of cancer. In this work a new computa- tional model (3D space and time) of LITT is presented. Using an arbitrary small number (<20) of optical ¯bers, multiple low energy laser light sources are applied internal to an arbitrary shaped tumor in the human liver. The power and position of each source can be chosen arbitrary. Each source is a spherical point source emitting light isotropically. The model consists of two, semi{coupled partial di®erential equations (PDEs) describing the light distribution and the heat absorption in the target tissue. Since water is a dominant tissue component in both the healthy liver and the malignant tumor the wavelength of the laser is chosen in the NIR area (1,064 nm). This is expected to form an absorption contrast in favor of the tumor leading to high temperature and damage of the tumor cells. The new, fast computational model presented here opens for the possibility of evaluating the outcome of LITT by inspection of temperature ¯elds, and comparing these to measured histological damage due to heating. This combination is promising when evaluating the result of LITT prior to the actual treatment.
AB - Laser{induced thermo therapy (LITT) is an alternative, gentle therapy of cancer. In this work a new computa- tional model (3D space and time) of LITT is presented. Using an arbitrary small number (<20) of optical ¯bers, multiple low energy laser light sources are applied internal to an arbitrary shaped tumor in the human liver. The power and position of each source can be chosen arbitrary. Each source is a spherical point source emitting light isotropically. The model consists of two, semi{coupled partial di®erential equations (PDEs) describing the light distribution and the heat absorption in the target tissue. Since water is a dominant tissue component in both the healthy liver and the malignant tumor the wavelength of the laser is chosen in the NIR area (1,064 nm). This is expected to form an absorption contrast in favor of the tumor leading to high temperature and damage of the tumor cells. The new, fast computational model presented here opens for the possibility of evaluating the outcome of LITT by inspection of temperature ¯elds, and comparing these to measured histological damage due to heating. This combination is promising when evaluating the result of LITT prior to the actual treatment.
KW - semi{coupled PDEs
KW - water contrast
KW - LITT
KW - liver metastasis
U2 - 10.1117/12.831933
DO - 10.1117/12.831933
M3 - Article in proceedings
VL - Vol. 7373
BT - Therapeutic Laser Applications and Laser-Tissue Interactions IV
ER -