A combined genetic and multi medium approach revels new secondary metabolites in Aspergillus nidulans

Marie Louise Klejnstrup, Morten Thrane Nielsen, Jens Christian Frisvad, Uffe Hasbro Mortensen, Thomas Ostenfeld Larsen

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    Secondary metabolites are a diverse group of metabolites which serve as important natural sources of drugs for treating diseases. The availability of full genome sequences of several filamentous fungi has revealed a large genetic potential for production of secondary metabolites that are not observed under standard laboratory conditions. Genetic approaches have proven a fruitfull strategy towards the production and identification of these unknown metabolites. Examples include deletion of the cclA1 and laeA2 genes in A. nidulans which affects the expression of secondary metabolites including monodictyphenone and terrequinone A respectively. We have deleted the cclA gene in A. nidulans and grown the mutants on several complex media to provoke the production of secondary metabolites. This resulted in the production of several metabolites not previously reported from A. nidulans. Some of these have been reported from other Emericella spp or Aspergillus terreus.
    Original languageEnglish
    Publication date2011
    Publication statusPublished - 2011
    Event26th Fungal Genetics Conference - Pacific Grove, CA, United States
    Duration: 15 Mar 201120 Mar 2011
    Conference number: 26


    Conference26th Fungal Genetics Conference
    Country/TerritoryUnited States
    CityPacific Grove, CA
    Internet address

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