A brown Norway rat model based on intraperitoneal injections can distinguish between low-, medium-, and high-allergenic foods

The global population is expected to reach 9 billion by 2050, raising concerns about the nutritional supply. Introducing new foods to the market may pose health risks, including the potential of introducing new food allergies. While there are methods to predict the risk of inducing allergic reactions in already allergic patients by studying cross-reactivity, there is a current lack of models for predicting de novo sensitisation of new food proteins. Therefore, we aimed to develop a predictive Brown Norway rat model being able to rank foods according to their allergenicity in humans.