A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.

David Endesfelder, Nicholas McGranahan, Nicolai Juul Birkbak, Zoltan Imre Szallasi, Maik Kschischo, Trevor A. Graham, Charles Swanton

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    Abstract

    Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status. Chromosomal instability (CIN) is increasingly recognised as an important prognostic variable in solid tumours. In a breast cancer meta-analysis of 2423 patients we examine the relationship between clinicopathological parameters and two distinct chromosomal instability gene expression signatures in order to address whether younger age at diagnosis is associated with increased tumour genome instability. We find that CIN, assessed by the two independently derived CIN expression signatures, is significantly associated with increased tumour size, ER negative or HER2 positive disease, higher tumour grade and younger age at diagnosis in ER negative breast cancer. These data support the hypothesis that chromosomal instability may be a defining feature of breast cancer biology and clinical outcome.
    Original languageEnglish
    JournalOncoTarget
    Number of pages9
    ISSN1949-2553
    Publication statusPublished - 2011

    Bibliographical note

    Copyright: © Endesfelder et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License,
    which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Keywords

    • Breast cancer
    • Age
    • Chromosomal instability
    • Histopathological parameters

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