A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte

Zhongli Xu; Ling Ding; Christian Hertweck

doi:10.1002/anie.201008265

A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte

Zhongli Xu, Ling Ding, Christian Hertweck

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Sharing a branch: The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl-CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also incorporated into novel, antibacterial germicidins (see scheme). Such natural biocombinatorics are unparalleled in polyketide biosynthesis.

Original language	English
Journal	Angewandte chemie-international edition
Volume	50
Issue number	20
Pages (from-to)	4667-4670
Number of pages	4
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201008265
Publication status	Published - 2011
Externally published	Yes

Keywords

Combinatorial Biosynthesis
Divergolides
Extender Units
Germicidins
Polyketides

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abstract = "Sharing a branch: The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl-CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also incorporated into novel, antibacterial germicidins (see scheme). Such natural biocombinatorics are unparalleled in polyketide biosynthesis. ",

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AU - Ding, Ling

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AB - Sharing a branch: The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl-CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also incorporated into novel, antibacterial germicidins (see scheme). Such natural biocombinatorics are unparalleled in polyketide biosynthesis.

KW - Combinatorial Biosynthesis

KW - Divergolides

KW - Extender Units

KW - Germicidins

KW - Polyketides

U2 - 10.1002/anie.201008265

DO - 10.1002/anie.201008265

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JF - Angewandte Chemie International Edition

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A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte

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Keywords

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