A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte

Zhongli Xu, Ling Ding, Christian Hertweck

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Sharing a branch: The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl-CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also incorporated into novel, antibacterial germicidins (see scheme). Such natural biocombinatorics are unparalleled in polyketide biosynthesis. 
Original languageEnglish
JournalAngewandte chemie-international edition
Volume50
Issue number20
Pages (from-to)4667-4670
Number of pages4
ISSN1433-7851
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Combinatorial Biosynthesis
  • Divergolides
  • Extender Units
  • Germicidins
  • Polyketides

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