Abstract
Sharing a branch: The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl-CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also incorporated into novel, antibacterial germicidins (see scheme). Such natural biocombinatorics are unparalleled in polyketide biosynthesis.
Original language | English |
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Journal | Angewandte chemie-international edition |
Volume | 50 |
Issue number | 20 |
Pages (from-to) | 4667-4670 |
Number of pages | 4 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |
Keywords
- Combinatorial Biosynthesis
- Divergolides
- Extender Units
- Germicidins
- Polyketides