Abstract
| Original language | English |
|---|---|
| Journal | Journal of Internal Medicine |
| Volume | 285 |
| Issue number | 1 |
| Pages (from-to) | 118-123 |
| Number of pages | 6 |
| ISSN | 0954-6820 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Atherosclerosis
- Biomarkers
- Collagen
- Extracellular matrix
- Inflammation
Cite this
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A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis. / Nielsen, S. Holm; Tengryd, C.; Edsfeldt, A.; Brix, S.; Genovese, F.; Bengtsson, E.; Karsdal, M.; Leeming, D. J.; Nilsson, J.; Goncalves, I.
In: Journal of Internal Medicine, Vol. 285, No. 1, 2019, p. 118-123.Research output: Contribution to journal › Journal article › Communication
TY - JOUR
T1 - A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis
AU - Nielsen, S. Holm
AU - Tengryd, C.
AU - Edsfeldt, A.
AU - Brix, S.
AU - Genovese, F.
AU - Bengtsson, E.
AU - Karsdal, M.
AU - Leeming, D. J.
AU - Nilsson, J.
AU - Goncalves, I.
PY - 2019
Y1 - 2019
N2 - Objective Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-mediated COL1 biomarker, C1M, was associated with cardiovascular events, cardiovascular mortality and all-cause mortality in a large prospective cohort of patients with known atherosclerosis. Methods Serum from 787 patients who underwent a carotid endarterectomy was included. Circulating levels of C1M were measured in serum. A total of 473 patients were followed for 6 years after surgery. Associations between C1M and incidence of cardiovascular events, cardiovascular mortality and all-cause mortality were assessed by Kaplan-Meier curves and Cox regression analysis. Results A total of 101 (21.4%) patients suffered from nonfatal cardiovascular events during the follow-up period, and 64 (13.5%) patients died. Of these, 39 (60.9%) died from cardiovascular diseases. Patients with C1M levels above the median were significantly associated with cardiovascular events, cardiovascular mortality and all-cause mortality (P < 0.001, P = 0.004 and P < 0.001, respectively). C1M was included in the final model for prediction of cardiovascular events (HR 2.15, 95% CI 1.40-3.32, P = 0.001), cardiovascular mortality (HR 2.20, 95% CI 1.07-4.51, P = 0.031) and all-cause mortality (HR 2.98 95% CI 1.67-5.33, P = < 0.001). Conclusions In patients with atherosclerotic carotid lesions, high levels of C1M predicted cardiovascular events, cardiovascular mortality and all-cause mortality. These findings emphasize the importance of remodelling mechanisms in atherosclerosis that are now becoming more and more explored.
AB - Objective Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-mediated COL1 biomarker, C1M, was associated with cardiovascular events, cardiovascular mortality and all-cause mortality in a large prospective cohort of patients with known atherosclerosis. Methods Serum from 787 patients who underwent a carotid endarterectomy was included. Circulating levels of C1M were measured in serum. A total of 473 patients were followed for 6 years after surgery. Associations between C1M and incidence of cardiovascular events, cardiovascular mortality and all-cause mortality were assessed by Kaplan-Meier curves and Cox regression analysis. Results A total of 101 (21.4%) patients suffered from nonfatal cardiovascular events during the follow-up period, and 64 (13.5%) patients died. Of these, 39 (60.9%) died from cardiovascular diseases. Patients with C1M levels above the median were significantly associated with cardiovascular events, cardiovascular mortality and all-cause mortality (P < 0.001, P = 0.004 and P < 0.001, respectively). C1M was included in the final model for prediction of cardiovascular events (HR 2.15, 95% CI 1.40-3.32, P = 0.001), cardiovascular mortality (HR 2.20, 95% CI 1.07-4.51, P = 0.031) and all-cause mortality (HR 2.98 95% CI 1.67-5.33, P = < 0.001). Conclusions In patients with atherosclerotic carotid lesions, high levels of C1M predicted cardiovascular events, cardiovascular mortality and all-cause mortality. These findings emphasize the importance of remodelling mechanisms in atherosclerosis that are now becoming more and more explored.
KW - Atherosclerosis
KW - Biomarkers
KW - Collagen
KW - Extracellular matrix
KW - Inflammation
U2 - 10.1111/joim.12819
DO - 10.1111/joim.12819
M3 - Journal article
VL - 285
SP - 118
EP - 123
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
SN - 0954-6820
IS - 1
ER -