89Zr Radiochemistry for Positron Emission Tomography - See more at: http://www.eurekaselect.com/88304/article#sthash.7KvNBDl3.dpuf

Gregory W. Severin, Jonathan W. Engle, Todd E. Barnhart, R. J. Nickles

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.
Original languageEnglish
JournalMedicinal Chemistry
Volume7
Issue number5
Pages (from-to)389-394
ISSN1573-4064
DOIs
Publication statusPublished - 2011
Externally publishedYes

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