89Zr Radiochemistry for Positron Emission Tomography - See more at: http://www.eurekaselect.com/88304/article#sthash.7KvNBDl3.dpuf

Gregory W. Severin; Jonathan W. Engle; Todd E. Barnhart; R. J. Nickles

doi:10.2174/157340611796799186

89Zr Radiochemistry for Positron Emission Tomography - See more at: http://www.eurekaselect.com/88304/article#sthash.7KvNBDl3.dpuf

Gregory W. Severin, Jonathan W. Engle, Todd E. Barnhart, R. J. Nickles

University of Wisconsin-Madison

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.

Original language	English
Journal	Medicinal Chemistry
Volume	7
Issue number	5
Pages (from-to)	389-394
ISSN	1573-4064
DOIs	https://doi.org/10.2174/157340611796799186
Publication status	Published - 2011
Externally published	Yes

Access to Document

10.2174/157340611796799186

OpenUrl availability

Full text

Cite this

@article{56a7798d62fc45edba4aa21ac2b162e2,

title = "89Zr Radiochemistry for Positron Emission Tomography - See more at: http://www.eurekaselect.com/88304/article#sthash.7KvNBDl3.dpuf",

abstract = "The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET. ",

author = "Severin, {Gregory W.} and Engle, {Jonathan W.} and Barnhart, {Todd E.} and Nickles, {R. J.}",

year = "2011",

doi = "10.2174/157340611796799186",

language = "English",

volume = "7",

pages = "389--394",

journal = "Medicinal Chemistry",

issn = "1573-4064",

publisher = "Bentham Science Publishers Ltd.",

number = "5",

}

TY - JOUR

T1 - 89Zr Radiochemistry for Positron Emission Tomography - See more at: http://www.eurekaselect.com/88304/article#sthash.7KvNBDl3.dpuf

AU - Severin, Gregory W.

AU - Engle, Jonathan W.

AU - Barnhart, Todd E.

AU - Nickles, R. J.

PY - 2011

Y1 - 2011

N2 - The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.

AB - The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.

U2 - 10.2174/157340611796799186

DO - 10.2174/157340611796799186

M3 - Journal article

SN - 1573-4064

VL - 7

SP - 389

EP - 394

JO - Medicinal Chemistry

JF - Medicinal Chemistry

IS - 5

ER -

89Zr Radiochemistry for Positron Emission Tomography - See more at: http://www.eurekaselect.com/88304/article#sthash.7KvNBDl3.dpuf

Abstract

Access to Document

OpenUrl availability

Fingerprint

Cite this