Abstract
Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione- dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
| Original language | English |
|---|---|
| IPC | C12N9/00; C12N9/02; C12N9/04; C12P7/42; C12P7/52 |
| Patent number | WO2014198841 |
| Filing date | 18/12/2014 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 14/06/2013 |
| Priority number | EP20130172151 |
| Publication status | Published - 2014 |