3HP tolerance

Kanchana Rueksomtawin Kildegaard (Inventor), Irina Borodina (Inventor), Jochen Förster (Inventor), Jens Nielsen (Inventor)

Research output: Patent

180 Downloads (Pure)

Abstract

Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione- dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.

Original languageEnglish
IPCC12N9/00; C12N9/02; C12N9/04; C12P7/42; C12P7/52
Patent number WO2014198841
Filing date18/12/2014
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date14/06/2013
Priority numberEP20130172151
Publication statusPublished - 2014

Bibliographical note

Also published as: US2016130613 (A1); EP3008179 (A1)

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