3D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery

Tien-Jen Chang*, Rolf Bech Kjeldsen*, Juliane Fjelrad Christfort, Eduard Marzo Vila, Tommy Sonne Alstrøm, Kinga Zór, En-Te Hwu, Line Hagner Nielsen, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

96 Downloads (Pure)


During the past decades, microdevices have been evaluated as a means to overcome challenges within oral drug delivery, thus improving bioavailability. Fabrication of microdevices is often limited to planar or simple 3D designs. Therefore, this work explores how microscale stereolithography 3D printing can be used to fabricate radiopaque microcontainers with enhanced mucoadhesive geometries, which can enhance bioavailability by increasing gastrointestinal retention. Ex vivo force measurements suggest increased mucoadhesion of microcontainers with adhering features, such as pillars and arrows, compared to a neutral design. In vivo studies, utilizing planar x-ray imaging, show time dependent gastrointestinal location of microcontainers, whereas computed tomography scanning and cryogenic scanning electron microscopy reveal information about their spatial dynamics and mucosal interactions. For the first time, the effect of 3D microdevice modifications on gastrointestinal retention is traced in vivo, and the applied methods provide a much-needed approach for investigating the impact of device design on gastrointestinal retention. This article is protected by copyright. All rights reserved.

Original languageEnglish
Article number2201897
JournalAdvanced Healthcare Materials
Issue number4
Number of pages12
Publication statusPublished - 2023


Dive into the research topics of '3D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery'. Together they form a unique fingerprint.

Cite this