3D Printed Flow Phantoms With Fiducial Markers for Super-Resolution Ultrasound Imaging

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

The improved resolution provided by ultrasound super-resolution imaging (SRI) sets new demands on the fabrication of phantoms for the validation and verification of the technique. Phantoms should resemble tissue and replicate the 3D nature of tissue vasculature at the microvascular scale. This paper presents a potential method for creating complex 3D phantoms, via 3D printing of water-filled polymer networks. By using a custom-built stereolithographic printer, projected light of the desired patterns converts an aqueous poly(ethylene glycol) diacrylate (PEGDA) solution into a hydrogel, a material capable of containing 75 wt% of water. Due to the hydrogel mainly consisting of water, it will, from an acoustical point of view, respond very similar to tissue. A method for printing cavities as small as (100 μm)3 is demonstrated, and a 3D printed flow phantom containing channels with cross sections of (200 μm)2 is presented. The designed structures are geometrically manufactured with a 2% increase in dimensions. The potential for further reduction of the flow phantom channels size, makes 3D printing a promising method for obtaining microvascular-like structures.
Original languageEnglish
Title of host publication 2018 IEEE International Ultrasonics Symposium (IUS)
Number of pages4
PublisherIEEE
Publication date2018
ISBN (Electronic)978-1-5386-3425-7
DOIs
Publication statusPublished - 2018
Event2018 IEEE International Ultrasonics Symposium - Portopia Hotel, Kobe, Japan
Duration: 22 Oct 201825 Oct 2018
http://sites.ieee.org/ius-2018/

Conference

Conference2018 IEEE International Ultrasonics Symposium
LocationPortopia Hotel
CountryJapan
CityKobe
Period22/10/201825/10/2018
Internet address

Cite this

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title = "3D Printed Flow Phantoms With Fiducial Markers for Super-Resolution Ultrasound Imaging",
abstract = "The improved resolution provided by ultrasound super-resolution imaging (SRI) sets new demands on the fabrication of phantoms for the validation and verification of the technique. Phantoms should resemble tissue and replicate the 3D nature of tissue vasculature at the microvascular scale. This paper presents a potential method for creating complex 3D phantoms, via 3D printing of water-filled polymer networks. By using a custom-built stereolithographic printer, projected light of the desired patterns converts an aqueous poly(ethylene glycol) diacrylate (PEGDA) solution into a hydrogel, a material capable of containing 75 wt{\%} of water. Due to the hydrogel mainly consisting of water, it will, from an acoustical point of view, respond very similar to tissue. A method for printing cavities as small as (100 μm)3 is demonstrated, and a 3D printed flow phantom containing channels with cross sections of (200 μm)2 is presented. The designed structures are geometrically manufactured with a 2{\%} increase in dimensions. The potential for further reduction of the flow phantom channels size, makes 3D printing a promising method for obtaining microvascular-like structures.",
author = "Ommen, {Martin Lind} and Mikkel Schou and Rujing Zhang and {Villag{\'o}mez Hoyos}, {Carlos Armando} and Jensen, {J{\o}rgen Arendt} and Larsen, {Niels Bent} and Thomsen, {Erik Vilain}",
year = "2018",
doi = "10.1109/ULTSYM.2018.8580217",
language = "English",
booktitle = "2018 IEEE International Ultrasonics Symposium (IUS)",
publisher = "IEEE",
address = "United States",

}

Ommen, ML, Schou, M, Zhang, R, Villagómez Hoyos, CA, Jensen, JA, Larsen, NB & Thomsen, EV 2018, 3D Printed Flow Phantoms With Fiducial Markers for Super-Resolution Ultrasound Imaging. in 2018 IEEE International Ultrasonics Symposium (IUS). IEEE, 2018 IEEE International Ultrasonics Symposium, Kobe, Japan, 22/10/2018. https://doi.org/10.1109/ULTSYM.2018.8580217

3D Printed Flow Phantoms With Fiducial Markers for Super-Resolution Ultrasound Imaging. / Ommen, Martin Lind; Schou, Mikkel; Zhang, Rujing; Villagómez Hoyos, Carlos Armando; Jensen, Jørgen Arendt; Larsen, Niels Bent; Thomsen, Erik Vilain.

2018 IEEE International Ultrasonics Symposium (IUS). IEEE, 2018.

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

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AU - Thomsen, Erik Vilain

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N2 - The improved resolution provided by ultrasound super-resolution imaging (SRI) sets new demands on the fabrication of phantoms for the validation and verification of the technique. Phantoms should resemble tissue and replicate the 3D nature of tissue vasculature at the microvascular scale. This paper presents a potential method for creating complex 3D phantoms, via 3D printing of water-filled polymer networks. By using a custom-built stereolithographic printer, projected light of the desired patterns converts an aqueous poly(ethylene glycol) diacrylate (PEGDA) solution into a hydrogel, a material capable of containing 75 wt% of water. Due to the hydrogel mainly consisting of water, it will, from an acoustical point of view, respond very similar to tissue. A method for printing cavities as small as (100 μm)3 is demonstrated, and a 3D printed flow phantom containing channels with cross sections of (200 μm)2 is presented. The designed structures are geometrically manufactured with a 2% increase in dimensions. The potential for further reduction of the flow phantom channels size, makes 3D printing a promising method for obtaining microvascular-like structures.

AB - The improved resolution provided by ultrasound super-resolution imaging (SRI) sets new demands on the fabrication of phantoms for the validation and verification of the technique. Phantoms should resemble tissue and replicate the 3D nature of tissue vasculature at the microvascular scale. This paper presents a potential method for creating complex 3D phantoms, via 3D printing of water-filled polymer networks. By using a custom-built stereolithographic printer, projected light of the desired patterns converts an aqueous poly(ethylene glycol) diacrylate (PEGDA) solution into a hydrogel, a material capable of containing 75 wt% of water. Due to the hydrogel mainly consisting of water, it will, from an acoustical point of view, respond very similar to tissue. A method for printing cavities as small as (100 μm)3 is demonstrated, and a 3D printed flow phantom containing channels with cross sections of (200 μm)2 is presented. The designed structures are geometrically manufactured with a 2% increase in dimensions. The potential for further reduction of the flow phantom channels size, makes 3D printing a promising method for obtaining microvascular-like structures.

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