3D Hyperpolarized C-13 EPI with Calibrationless Parallel Imaging

Jeremy W. Gordon*, Rie Beck Hansen, Peter J. Shin, Yesu Feng, Daniel B. Vigneron, Peder E. Z. Larson

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    With the translation of metabolic MRI with hyperpolarized 13C agents into the clinic, imaging approaches will require large volumetric FOVs to support clinical applications. Parallel imaging techniques will be crucial to increasing volumetric scan coverage while minimizing RF requirements and temporal resolution. Calibrationless parallel imaging approaches are well-suited for this application because they eliminate the need to acquire coil profile maps or auto-calibration data. In this work, we explored the utility of a calibrationless parallel imaging method (SAKE) and corresponding sampling strategies to accelerate and undersample hyperpolarized 13C data using 3D blipped EPI acquisitions and multichannel receive coils, and demonstrated its application in a human study of [1-13C]pyruvate metabolism.
    Original languageEnglish
    JournalJournal of Magnetic Resonance
    Pages (from-to)92-99
    Publication statusPublished - 2018


    • Hyperpolarization
    • Parallel Imaging
    • SAKE
    • Pyruvate
    • EPI
    • C13


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