3D cell-laden polymers to release bioactive products in the eye

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

  • Author: Orive, Gorka

    University of the Basque Country, Spain

  • Author: Santos-Vizcaino, Edorta

    University of the Basque Country, Spain

  • Author: Pedraz, Jose Luis

    University of the Basque Country, Spain

  • Author: Hernandez, Rosa Maria

    University of the Basque Country, Spain

  • Author: Vela Ramirez, Julia E.

    University of Texas at Austin, United States

  • Author: Dolatshahi-Pirouz, Alireza

    Department of Health Technology, Technical University of Denmark, Produktionstorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Khademhosseini, Ali

    University of California at Los Angeles, United States

  • Author: Peppas, Nicholas A.

    University of Texas at Austin, United States

  • Author: Emerich, Dwaine F.

    Gloriana Therapeutics, Inc., United States

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Millions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; especially when attempting to deliver drugs to the posterior eye or trying to regenerate the diseased retina. Cell-based therapies offer a significant potential advancement in these situations. In particular, encapsulating, or immunoisolating, cells within implantable, semi-permeable membranes has emerged as a clinically viable means of delivering therapeutic molecules to the eye for indefinite periods of time. The optimization of encapsulation device designs is occurring together with refinements in biomaterials, genetic engineering, and stem-cell production, yielding, for the first time, the possibility of widespread therapeutic use of this technology. Here, we highlight the status of the most advanced and widely explored iteration of cell encapsulation with an eye toward translating the potential of this technological approach to the medical reality.
Original languageEnglish
JournalProgress in Retinal and Eye Research
Volume68
Pages (from-to)67-82
ISSN1350-9462
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Cell therapy, Drug delivery, Encapsulated cell technology, Encapsulation, Ophthalmic diseases, Protein

ID: 159153323