3D cell-laden polymers to release bioactive products in the eye

Gorka Orive, Edorta Santos-Vizcaino, Jose Luis Pedraz, Rosa Maria Hernandez, Julia E. Vela Ramirez, Alireza Dolatshahi-Pirouz, Ali Khademhosseini, Nicholas A. Peppas, Dwaine F. Emerich*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Millions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; especially when attempting to deliver drugs to the posterior eye or trying to regenerate the diseased retina. Cell-based therapies offer a significant potential advancement in these situations. In particular, encapsulating, or immunoisolating, cells within implantable, semi-permeable membranes has emerged as a clinically viable means of delivering therapeutic molecules to the eye for indefinite periods of time. The optimization of encapsulation device designs is occurring together with refinements in biomaterials, genetic engineering, and stem-cell production, yielding, for the first time, the possibility of widespread therapeutic use of this technology. Here, we highlight the status of the most advanced and widely explored iteration of cell encapsulation with an eye toward translating the potential of this technological approach to the medical reality.
Original languageEnglish
JournalProgress in Retinal and Eye Research
Volume68
Pages (from-to)67-82
ISSN1350-9462
DOIs
Publication statusPublished - 2019

Keywords

  • Cell therapy
  • Drug delivery
  • Encapsulated cell technology
  • Encapsulation
  • Ophthalmic diseases
  • Protein

Cite this

Orive, G., Santos-Vizcaino, E., Pedraz, J. L., Hernandez, R. M., Vela Ramirez, J. E., Dolatshahi-Pirouz, A., ... Emerich, D. F. (2019). 3D cell-laden polymers to release bioactive products in the eye. Progress in Retinal and Eye Research, 68, 67-82. https://doi.org/10.1016/j.preteyeres.2018.10.002
Orive, Gorka ; Santos-Vizcaino, Edorta ; Pedraz, Jose Luis ; Hernandez, Rosa Maria ; Vela Ramirez, Julia E. ; Dolatshahi-Pirouz, Alireza ; Khademhosseini, Ali ; Peppas, Nicholas A. ; Emerich, Dwaine F. / 3D cell-laden polymers to release bioactive products in the eye. In: Progress in Retinal and Eye Research. 2019 ; Vol. 68. pp. 67-82.
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abstract = "Millions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; especially when attempting to deliver drugs to the posterior eye or trying to regenerate the diseased retina. Cell-based therapies offer a significant potential advancement in these situations. In particular, encapsulating, or immunoisolating, cells within implantable, semi-permeable membranes has emerged as a clinically viable means of delivering therapeutic molecules to the eye for indefinite periods of time. The optimization of encapsulation device designs is occurring together with refinements in biomaterials, genetic engineering, and stem-cell production, yielding, for the first time, the possibility of widespread therapeutic use of this technology. Here, we highlight the status of the most advanced and widely explored iteration of cell encapsulation with an eye toward translating the potential of this technological approach to the medical reality.",
keywords = "Cell therapy, Drug delivery, Encapsulated cell technology, Encapsulation, Ophthalmic diseases, Protein",
author = "Gorka Orive and Edorta Santos-Vizcaino and Pedraz, {Jose Luis} and Hernandez, {Rosa Maria} and {Vela Ramirez}, {Julia E.} and Alireza Dolatshahi-Pirouz and Ali Khademhosseini and Peppas, {Nicholas A.} and Emerich, {Dwaine F.}",
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Orive, G, Santos-Vizcaino, E, Pedraz, JL, Hernandez, RM, Vela Ramirez, JE, Dolatshahi-Pirouz, A, Khademhosseini, A, Peppas, NA & Emerich, DF 2019, '3D cell-laden polymers to release bioactive products in the eye', Progress in Retinal and Eye Research, vol. 68, pp. 67-82. https://doi.org/10.1016/j.preteyeres.2018.10.002

3D cell-laden polymers to release bioactive products in the eye. / Orive, Gorka; Santos-Vizcaino, Edorta; Pedraz, Jose Luis; Hernandez, Rosa Maria; Vela Ramirez, Julia E.; Dolatshahi-Pirouz, Alireza; Khademhosseini, Ali; Peppas, Nicholas A.; Emerich, Dwaine F.

In: Progress in Retinal and Eye Research, Vol. 68, 2019, p. 67-82.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Orive, Gorka

AU - Santos-Vizcaino, Edorta

AU - Pedraz, Jose Luis

AU - Hernandez, Rosa Maria

AU - Vela Ramirez, Julia E.

AU - Dolatshahi-Pirouz, Alireza

AU - Khademhosseini, Ali

AU - Peppas, Nicholas A.

AU - Emerich, Dwaine F.

PY - 2019

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AB - Millions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; especially when attempting to deliver drugs to the posterior eye or trying to regenerate the diseased retina. Cell-based therapies offer a significant potential advancement in these situations. In particular, encapsulating, or immunoisolating, cells within implantable, semi-permeable membranes has emerged as a clinically viable means of delivering therapeutic molecules to the eye for indefinite periods of time. The optimization of encapsulation device designs is occurring together with refinements in biomaterials, genetic engineering, and stem-cell production, yielding, for the first time, the possibility of widespread therapeutic use of this technology. Here, we highlight the status of the most advanced and widely explored iteration of cell encapsulation with an eye toward translating the potential of this technological approach to the medical reality.

KW - Cell therapy

KW - Drug delivery

KW - Encapsulated cell technology

KW - Encapsulation

KW - Ophthalmic diseases

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JO - Progress in Retinal and Eye Research

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SN - 1350-9462

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