3D biomaterial models of human brain disease

Janko Kajtez*, Fredrik Nilsson, Alessandro Fiorenzano, Malin Parmar, Jenny Emnéus

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials engineering, and biofabrication, have quickly shown great potential to mimic biochemical composition, structural properties, and cellular morphology and diversity found in the native brain tissue. Crucial to these developments have been the advancements in stem cell technology and cell reprogramming protocols that allow reproducible generation of human subtype-specific neurons and glia in laboratory conditions. At the same time, biomaterials have been designed to provide cells in 3D with a microenvironment that mimics functional and structural aspects of the native extracellular matrix with increasing fidelity. In this article, we review the use of biomaterials in 3D in vitro models of neurological disorders with focus on hydrogel technology and with biochemical composition and physical properties of the in vivo environment as reference.
Original languageEnglish
Article number105043
JournalNeurochemistry International
Volume147
Number of pages13
ISSN0197-0186
DOIs
Publication statusPublished - 2021

Keywords

  • 3D culture
  • Brain organoids
  • Hydrogels
  • Brain disease
  • Biomaterials
  • Brain ECM

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